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{{STRUCTURE_4fev| PDB=4fev | SCENE= }} | {{STRUCTURE_4fev| PDB=4fev | SCENE= }} | ||
===Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate kanamycin and small molecule inhibitor pyrazolopyrimidine PP1=== | ===Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate kanamycin and small molecule inhibitor pyrazolopyrimidine PP1=== | ||
{{ABSTRACT_PUBMED_23758273}} | |||
==About this Structure== | |||
[[4fev]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Acinetobacter_baumannii_aye Acinetobacter baumannii aye]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FEV OCA]. | |||
== | ==Reference== | ||
<ref group="xtra">PMID:023758273</ref><references group="xtra"/><references/> | |||
[[Category: Acinetobacter baumannii]] | [[Category: Acinetobacter baumannii aye]] | ||
[[Category: Kanamycin kinase]] | [[Category: Kanamycin kinase]] | ||
[[Category: Anderson, W F.]] | [[Category: Anderson, W F.]] | ||
Revision as of 10:56, 30 June 2013
Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate kanamycin and small molecule inhibitor pyrazolopyrimidine PP1Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate kanamycin and small molecule inhibitor pyrazolopyrimidine PP1
Template:ABSTRACT PUBMED 23758273
About this StructureAbout this Structure
4fev is a 6 chain structure with sequence from Acinetobacter baumannii aye. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Stogios PJ, Spanogiannopoulos P, Evdokimova E, Egorova O, Shakya T, Todorovic N, Capretta A, Wright GD, Savchenko A. Structure-guided optimization of protein kinase inhibitors reverses aminoglycoside antibiotic resistance. Biochem J. 2013 Jun 12. PMID:23758273 doi:10.1042/BJ20130317
Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCACategories:
- Acinetobacter baumannii aye
- Kanamycin kinase
- Anderson, W F.
- CSGID, Center for Structural Genomics of Infectious Diseases.
- Egorova, O.
- Evdokimova, E.
- Leo, R Di.
- Minasov, G.
- Savchenko, A.
- Shakya, T.
- Spanogiannopoulos, P.
- Stogios, P J.
- Wawrzak, Z.
- Wright, G D.
- Alpha/beta protein
- Aminoglycoside phosphotransferase
- Aminoglycoside
- Antibiotic resistance
- Center for structural genomics of infectious disease
- Csgid
- Eukaryotic protein kinase-like fold
- Gtp
- Intracellular
- Kanamycin
- National institute of allergy and infectious disease
- Niaid
- Phosphotransferase
- Pp1
- Protein kinase inhibitor
- Pyrazolopyrimidine
- Transferase
- Transferase-transferase inhibitor complex