3b28: Difference between revisions
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{{STRUCTURE_3b28| PDB=3b28 | SCENE= }} | {{STRUCTURE_3b28| PDB=3b28 | SCENE= }} | ||
===Hsp90 alpha N-terminal domain in complex with an inhibitor CH5015765=== | ===Hsp90 alpha N-terminal domain in complex with an inhibitor CH5015765=== | ||
{{ABSTRACT_PUBMED_21875802}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[3b28]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B28 OCA]. | [[3b28]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B28 OCA]. | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:021875802</ref><references group="xtra"/> | <ref group="xtra">PMID:021875802</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Fukami, T A.]] | [[Category: Fukami, T A.]] | ||
[[Category: Ono, N.]] | [[Category: Ono, N.]] | ||
[[Category: Chaperone-chaperone inhibitor complex]] | [[Category: Chaperone-chaperone inhibitor complex]] | ||