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{{STRUCTURE_4fxr| PDB=4fxr | SCENE= }} | |||
===Crystal structure of the mutant T159V.R203A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP=== | |||
{{ABSTRACT_PUBMED_23030629}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/PYRF_METTH PYRF_METTH]] Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).[HAMAP-Rule:MF_01200_A] | |||
==About this Structure== | |||
[[4fxr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus_str._delta_h Methanothermobacter thermautotrophicus str. delta h]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FXR OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023030629</ref><references group="xtra"/><references/> | |||
[[Category: Methanothermobacter thermautotrophicus str. delta h]] | |||
[[Category: Orotidine-5'-phosphate decarboxylase]] | |||
[[Category: Almo, S C.]] | |||
[[Category: Desai, B.]] | |||
[[Category: Fedorov, A A.]] | |||
[[Category: Fedorov, E V.]] | |||
[[Category: Gerlt, J A.]] | |||
[[Category: Inhibitor bmp]] | |||
[[Category: Lyase-lyase inhibitor complex]] | |||
[[Category: Tim barrel]] | |||
Revision as of 09:25, 20 June 2013
Crystal structure of the mutant T159V.R203A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMPCrystal structure of the mutant T159V.R203A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP
Template:ABSTRACT PUBMED 23030629
FunctionFunction
[PYRF_METTH] Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).[HAMAP-Rule:MF_01200_A]
About this StructureAbout this Structure
4fxr is a 2 chain structure with sequence from Methanothermobacter thermautotrophicus str. delta h. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Desai BJ, Wood BM, Fedorov AA, Fedorov EV, Goryanova B, Amyes TL, Richard JP, Almo SC, Gerlt JA. Conformational Changes in Orotidine 5'-Monophosphate Decarboxylase: A Structure-Based Explanation for How the 5'-Phosphate Group Activates the Enzyme. Biochemistry. 2012 Oct 17. PMID:23030629 doi:10.1021/bi301188k