2m7h: Difference between revisions

Revision as of 09:22, 20 June 2013

The C-terminal Region of Disintegrin Modulate its 3D Conformation and Cooperate with RGD Loop in Regulating Integrin alpha-IIb beta-3 RecognitionThe C-terminal Region of Disintegrin Modulate its 3D Conformation and Cooperate with RGD Loop in Regulating Integrin alpha-IIb beta-3 Recognition

FunctionFunction

[VM2RH_CALRH] Metalloproteinase rhodostoxin: snake venom metalloproteinase that impairs hemostasis in the envenomed animal (By similarity). Disintegrin rhodostomin: inhibit platelet aggregation induced by ADP, thrombin, platelet-activating factor and collagen. Acts by inhibiting fibrinogen interaction with platelet receptors GPIIb/GPIIIa (ITGA2B/ITGB3).

About this StructureAbout this Structure

2m7h is a 1 chain structure with sequence from Calloselasma rhodostoma. Full experimental information is available from OCA.

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_2m7h|  PDB=2m7h  |  SCENE=  }}
+===The C-terminal Region of Disintegrin Modulate its 3D Conformation and Cooperate with RGD Loop in Regulating Integrin alpha-IIb beta-3 Recognition===
-The entry 2m7h is ON HOLD
+==Function==
+[[http://www.uniprot.org/uniprot/VM2RH_CALRH VM2RH_CALRH]] Metalloproteinase rhodostoxin: snake venom metalloproteinase that impairs hemostasis in the envenomed animal (By similarity).  Disintegrin rhodostomin: inhibit platelet aggregation induced by ADP, thrombin, platelet-activating factor and collagen. Acts by inhibiting fibrinogen interaction with platelet receptors GPIIb/GPIIIa (ITGA2B/ITGB3).
-Authors: Chuang, W., Chang, Y.
+==About this Structure==
+[[2m7h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Calloselasma_rhodostoma Calloselasma rhodostoma]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M7H OCA].
-Description: The C-terminal Region of Disintegrin Modulate its 3D Conformation and Cooperate with RGD Loop in Regulating Integrin alpha-IIb beta-3 Recognition
+[[Category: Calloselasma rhodostoma]]
+[[Category: Chang, Y.]]
+[[Category: Chuang, W.]]
+[[Category: C-terminal region mutation]]
+[[Category: Hydrolase]]
+[[Category: Integrin alpha-iib beta-3]]
+[[Category: Rgd motif]]
+[[Category: Rhodostomin muant]]