4kit: Difference between revisions

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-'''Unreleased structure'''
+{{STRUCTURE_4kit|  PDB=4kit  |  SCENE=  }}
+===Crystal structure of human Brr2 in complex with the Prp8 Jab1/MPN domain===
+{{ABSTRACT_PUBMED_23704370}}
-The entry 4kit is ON HOLD
+==Disease==
+[[http://www.uniprot.org/uniprot/U520_HUMAN U520_HUMAN]] Retinitis pigmentosa. Retinitis pigmentosa 33 (RP33) [MIM:[http://omim.org/entry/610359 610359]]: A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. Note=The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:16723661</ref> <ref>PMID:23045696</ref> <ref>PMID:19878916</ref> <ref>PMID:19710410</ref> <ref>PMID:21618346</ref>  [[http://www.uniprot.org/uniprot/PRP8_HUMAN PRP8_HUMAN]] Defects in PRPF8 are the cause of retinitis pigmentosa type 13 (RP13) [MIM:[http://omim.org/entry/600059 600059]]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP13 inheritance is autosomal dominant.<ref>PMID:17317632</ref> <ref>PMID:11468273</ref> [:]<ref>PMID:11910553</ref> <ref>PMID:12714658</ref>
-Authors: Wahl, M.C., Wandersleben, T., Santos, K.F.
+==Function==
+[[http://www.uniprot.org/uniprot/U520_HUMAN U520_HUMAN]] RNA helicase that plays an essential role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes. Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome.<ref>PMID:16723661</ref> <ref>PMID:8670905</ref> <ref>PMID:9539711</ref> <ref>PMID:23045696</ref>  [[http://www.uniprot.org/uniprot/PRP8_HUMAN PRP8_HUMAN]] Central component of the spliceosome, which may play a role in aligning the pre-mRNA 5'- and 3'-exons for ligation. Interacts with U5 snRNA, and with pre-mRNA 5'-splice sites in B spliceosomes and 3'-splice sites in C spliceosomes.
-Description: Spliceosomal protein complex
+==About this Structure==
+[[4kit]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KIT OCA].
+==Reference==
+<ref group="xtra">PMID:023704370</ref><references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: RNA helicase]]
+[[Category: Santos, K F.]]
+[[Category: Wahl, M C.]]
+[[Category: Wandersleben, T.]]
+[[Category: Atp binding]]
+[[Category: Jab1/mpn domain]]
+[[Category: Pre-mrna splicing]]
+[[Category: Reca domain]]
+[[Category: Rna binding]]
+[[Category: Rna binding protein]]
+[[Category: Sec63 unit]]
+[[Category: Ubiquitin binding]]
+[[Category: Winged helix domain]]