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{{STRUCTURE_3zmh| PDB=3zmh | SCENE= }} | |||
===Structure of E.coli rhomboid protease GlpG in complex with monobactam L62=== | |||
{{ABSTRACT_PUBMED_23665170}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/GLPG_ECOLI GLPG_ECOLI]] Rhomboid-type serine protease that catalyzes intramembrane proteolysis.<ref>PMID:17099694</ref> <ref>PMID:16216077</ref> | |||
==About this Structure== | |||
[[3zmh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZMH OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023665170</ref><references group="xtra"/><references/> | |||
[[Category: Escherichia coli]] | |||
[[Category: Rhomboid protease]] | |||
[[Category: Freeman, M.]] | |||
[[Category: Large, J M.]] | |||
[[Category: Pierrat, O A.]] | |||
[[Category: Vinothkumar, K R.]] | |||
[[Category: Acyl enzyme]] | |||
[[Category: Anitbiotic]] | |||
[[Category: Beta lactam]] | |||
[[Category: Hydrolase]] | |||
[[Category: Intra-membrane protease]] | |||
Revision as of 19:28, 19 June 2013
Structure of E.coli rhomboid protease GlpG in complex with monobactam L62Structure of E.coli rhomboid protease GlpG in complex with monobactam L62
Template:ABSTRACT PUBMED 23665170
FunctionFunction
[GLPG_ECOLI] Rhomboid-type serine protease that catalyzes intramembrane proteolysis.[1] [2]
About this StructureAbout this Structure
3zmh is a 1 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Vinothkumar KR, Pierrat OA, Large JM, Freeman M. Structure of Rhomboid Protease in Complex with beta-Lactam Inhibitors Defines the S2' Cavity. Structure. 2013 May 7. pii: S0969-2126(13)00117-2. doi:, 10.1016/j.str.2013.03.013. PMID:23665170 doi:10.1016/j.str.2013.03.013
- ↑ Wu Z, Yan N, Feng L, Oberstein A, Yan H, Baker RP, Gu L, Jeffrey PD, Urban S, Shi Y. Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry. Nat Struct Mol Biol. 2006 Dec;13(12):1084-91. Epub 2006 Nov 10. PMID:17099694 doi:10.1038/nsmb1179
- ↑ Maegawa S, Ito K, Akiyama Y. Proteolytic action of GlpG, a rhomboid protease in the Escherichia coli cytoplasmic membrane. Biochemistry. 2005 Oct 18;44(41):13543-52. PMID:16216077 doi:10.1021/bi051363k