3zmz: Difference between revisions

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-'''Unreleased structure'''
+{{STRUCTURE_3zmz|  PDB=3zmz  |  SCENE=  }}
+===LSD1-CoREST in complex with PRSFAV peptide===
+{{ABSTRACT_PUBMED_23721412}}
-The entry 3zmz is ON HOLD
+==Function==
+[[http://www.uniprot.org/uniprot/RCOR1_HUMAN RCOR1_HUMAN]] Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation.<ref>PMID:11516394</ref> <ref>PMID:11171972</ref> <ref>PMID:12032298</ref> <ref>PMID:12399542</ref> <ref>PMID:12493763</ref> <ref>PMID:16140033</ref> <ref>PMID:16079794</ref>
-Authors: Tortorici, M., Borrello, M.T., Tardugno, M., Chiarelli, L.R., Pilotto, S., Ciossani, G., Vellore, N.A., Cowan, J., O'Connell, M., Mai, A., Baron, R., Ganesan, A., Mattevi, A.
+==About this Structure==
+[[3zmz]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZMZ OCA].
-Description:
+==Reference==
+<ref group="xtra">PMID:023721412</ref><references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: Baron, R.]]
+[[Category: Borrello, M T.]]
+[[Category: Chiarelli, L R.]]
+[[Category: Ciossani, G.]]
+[[Category: Connell, M O.]]
+[[Category: Cowan, J.]]
+[[Category: Ganesan, A.]]
+[[Category: Mai, A.]]
+[[Category: Mattevi, A.]]
+[[Category: Pilotto, S.]]
+[[Category: Tardugno, M.]]
+[[Category: Tortorici, M.]]
+[[Category: Vellore, N A.]]
+[[Category: Chromatin]]
+[[Category: Demethylase]]
+[[Category: Oxidoreductase]]
+[[Category: Transcription factor]]