4bi0: Difference between revisions
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{{STRUCTURE_4bi0| PDB=4bi0 | SCENE= }} | |||
===Scaffold Focused Virtual Screening: Prospective Application to the Discovery of TTK Inhibitor=== | |||
{{ABSTRACT_PUBMED_23672464}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN]] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref> | |||
==About this Structure== | |||
[[4bi0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BI0 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023672464</ref><references group="xtra"/><references/> | |||
[[Category: Dual-specificity kinase]] | |||
[[Category: Homo sapiens]] | |||
[[Category: Blagg, J.]] | |||
[[Category: Brown, N.]] | |||
[[Category: Langdon, S R.]] | |||
[[Category: Montfort, R L.M van.]] | |||
[[Category: Westwood, I M.]] | |||
[[Category: Mitosis]] | |||
[[Category: Protein kinase]] | |||
[[Category: Transferase]] | |||
Revision as of 18:56, 19 June 2013
Scaffold Focused Virtual Screening: Prospective Application to the Discovery of TTK InhibitorScaffold Focused Virtual Screening: Prospective Application to the Discovery of TTK Inhibitor
Template:ABSTRACT PUBMED 23672464
FunctionFunction
[TTK_HUMAN] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.[1]
About this StructureAbout this Structure
4bi0 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Langdon SR, Westwood IM, van Montfort RL, Brown N, Blagg J. Scaffold-Focused Virtual Screening: Prospective Application to the Discovery of TTK Inhibitors. J Chem Inf Model. 2013 May 24;53(5):1100-12. doi: 10.1021/ci400100c. Epub 2013, May 14. PMID:23672464 doi:10.1021/ci400100c
- ↑ Jelluma N, Brenkman AB, van den Broek NJ, Cruijsen CW, van Osch MH, Lens SM, Medema RH, Kops GJ. Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment. Cell. 2008 Jan 25;132(2):233-46. doi: 10.1016/j.cell.2007.11.046. PMID:18243099 doi:10.1016/j.cell.2007.11.046