1gjh: Difference between revisions
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==About this Structure== | ==About this Structure== | ||
[[1gjh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1g5o 1g5o]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GJH OCA]. | [[1gjh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1g5o 1g5o]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GJH OCA]. | ||
==Reference== | ==Reference== | ||
Revision as of 18:52, 19 June 2013
HUMAN BCL-2, ISOFORM 2HUMAN BCL-2, ISOFORM 2
Template:ABSTRACT PUBMED 11248023
DiseaseDisease
[BCL2_HUMAN] Note=A chromosomal aberration involving BCL2 has been found in chronic lymphatic leukemia. Translocation t(14;18)(q32;q21) with immunoglobulin gene regions. BCL2 mutations found in non-Hodgkin lymphomas carrying the chromosomal translocation could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions.
FunctionFunction
[BCL2_HUMAN] Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).[1]
About this StructureAbout this Structure
1gjh is a 1 chain structure with sequence from Homo sapiens. This structure supersedes the now removed PDB entry 1g5o. Full experimental information is available from OCA.
ReferenceReference
- ↑ Petros AM, Medek A, Nettesheim DG, Kim DH, Yoon HS, Swift K, Matayoshi ED, Oltersdorf T, Fesik SW. Solution structure of the antiapoptotic protein bcl-2. Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3012-7. Epub 2001 Feb 27. PMID:11248023 doi:10.1073/pnas.041619798
- ↑ Wei Y, Pattingre S, Sinha S, Bassik M, Levine B. JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol Cell. 2008 Jun 20;30(6):678-88. doi: 10.1016/j.molcel.2008.06.001. PMID:18570871 doi:10.1016/j.molcel.2008.06.001