3d1b: Difference between revisions
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{{STRUCTURE_3d1b| PDB=3d1b | SCENE= }} | {{STRUCTURE_3d1b| PDB=3d1b | SCENE= }} | ||
===Tetragonal crystal structure of Tas3 C-terminal alpha motif=== | ===Tetragonal crystal structure of Tas3 C-terminal alpha motif=== | ||
{{ABSTRACT_PUBMED_19394293}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/TAS3_SCHPO TAS3_SCHPO]] Has a role in the RNA interference (RNAi) pathway which is important for heterochromatin formation and accurate chromosome segregation. A member of the RNA-induced transcriptional silencing (RITS) complex which is involved in the biosynthesis of dsRNA from primer siRNAs provided by the RNA-directed RNA polymerase (RDRC) complex.<ref>PMID:15607976</ref> <ref>PMID:14704433</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:019394293</ref><references group="xtra"/> | <ref group="xtra">PMID:019394293</ref><references group="xtra"/><references/> | ||
[[Category: Schizosaccharomyces pombe]] | [[Category: Schizosaccharomyces pombe]] | ||
[[Category: Li, H.]] | [[Category: Li, H.]] | ||
Revision as of 18:37, 19 June 2013
Tetragonal crystal structure of Tas3 C-terminal alpha motifTetragonal crystal structure of Tas3 C-terminal alpha motif
Template:ABSTRACT PUBMED 19394293
FunctionFunction
[TAS3_SCHPO] Has a role in the RNA interference (RNAi) pathway which is important for heterochromatin formation and accurate chromosome segregation. A member of the RNA-induced transcriptional silencing (RITS) complex which is involved in the biosynthesis of dsRNA from primer siRNAs provided by the RNA-directed RNA polymerase (RDRC) complex.[1] [2]
About this StructureAbout this Structure
3d1b is a 3 chain structure with sequence from Schizosaccharomyces pombe. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Li H, Motamedi MR, Yip CK, Wang Z, Walz T, Patel DJ, Moazed D. An alpha motif at Tas3 C terminus mediates RITS cis spreading and promotes heterochromatic gene silencing. Mol Cell. 2009 Apr 24;34(2):155-67. PMID:19394293 doi:10.1016/j.molcel.2009.02.032
- ↑ Motamedi MR, Verdel A, Colmenares SU, Gerber SA, Gygi SP, Moazed D. Two RNAi complexes, RITS and RDRC, physically interact and localize to noncoding centromeric RNAs. Cell. 2004 Dec 17;119(6):789-802. PMID:15607976 doi:10.1016/j.cell.2004.11.034
- ↑ Verdel A, Jia S, Gerber S, Sugiyama T, Gygi S, Grewal SI, Moazed D. RNAi-mediated targeting of heterochromatin by the RITS complex. Science. 2004 Jan 30;303(5658):672-6. Epub 2004 Jan 2. PMID:14704433 doi:10.1126/science.1093686