2hck: Difference between revisions

[[Image:2hck.gif|left|200px]]<br />

<applet load="2hck" size="450" color="white" frame="true" align="right" spinBox="true"  

The crystal structure of the haematopoietic cell kinase Hck has been, determined at 2.6/2.9 A resolution. Inhibition of enzymatic activity is a, consequence of intramolecular interactions of the enzyme's Src-homology, domains SH2 and SH3, with concomitant displacement of elements of the, catalytic domain. The conformation of the active site has similarities, with that of inactive cyclin-dependent protein kinases.

2HCK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CA and QUE as [http://en.wikipedia.org/wiki/ligands ligands]. The following page contains interesting information on the relation of 2HCK with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb43_1.html Src Tyrosine Kinase]]. Active as [http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2HCK OCA].  

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