4ixe: Difference between revisions
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{{STRUCTURE_4ixe| PDB=4ixe | SCENE= }} | |||
===pcDHFR-NADPH-270=== | |||
{{ABSTRACT_PUBMED_23627352}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/DYR_PNECA DYR_PNECA]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | |||
==About this Structure== | |||
[[4ixe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pneumocystis_carinii Pneumocystis carinii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IXE OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023627352</ref><references group="xtra"/><references/> | |||
[[Category: Dihydrofolate reductase]] | |||
[[Category: Pneumocystis carinii]] | |||
[[Category: Cody, V.]] | |||
[[Category: Dihydrofolate reductase inhibitor cofactor ternary complex]] | |||
[[Category: Oxidoreductase-inhibitor complex]] | |||
[[Category: Reductase]] | |||
Revision as of 18:04, 19 June 2013
pcDHFR-NADPH-270pcDHFR-NADPH-270
Template:ABSTRACT PUBMED 23627352
FunctionFunction
[DYR_PNECA] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
About this StructureAbout this Structure
4ixe is a 1 chain structure with sequence from Pneumocystis carinii. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Gangjee A, Namjoshi OA, Raghavan S, Queener SF, Kisliuk RL, Cody V. Design, synthesis and molecular modeling of novel pyrido[2,3-d]pyrimidine analogs as antifolates: Application of Buchwald-Hartwig aminations of heterocycles. J Med Chem. 2013 Apr 29. PMID:23627352 doi:10.1021/jm400086g