4jnk: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older editNewer edit →
No edit summary
No edit summary
Line 1: Line 1:
'''Unreleased structure'''
{{STRUCTURE_4jnk|  PDB=4jnk  |  SCENE=  }}
===Lactate Dehydrogenase A in complex with inhibitor compound 22===
{{ABSTRACT_PUBMED_23628333}}


The entry 4jnk is ON HOLD until sometime in the future
==Disease==
[[http://www.uniprot.org/uniprot/LDHA_HUMAN LDHA_HUMAN]] Defects in LDHA are the cause of glycogen storage disease type 11 (GSD11) [MIM:[http://omim.org/entry/612933 612933]]. A metabolic disorder that results in exertional myoglobinuria, pain, cramps and easy fatigue.<ref>PMID:2334430</ref>  


Authors: Eigenbrot, C., Ultsch, M.
==About this Structure==
[[4jnk]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JNK OCA].  


Description: Lactate Dehydrogenase A in complex with inhibitor compound 22
==Reference==
<ref group="xtra">PMID:023628333</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: L-lactate dehydrogenase]]
[[Category: Eigenbrot, C.]]
[[Category: Ultsch, M.]]
[[Category: Alpha-beta]]
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
[[Category: Pyruvate reductase and lactate dehydrogenase]]

Revision as of 16:39, 19 June 2013

Template:STRUCTURE 4jnk

Lactate Dehydrogenase A in complex with inhibitor compound 22Lactate Dehydrogenase A in complex with inhibitor compound 22

Template:ABSTRACT PUBMED 23628333

DiseaseDisease

[LDHA_HUMAN] Defects in LDHA are the cause of glycogen storage disease type 11 (GSD11) [MIM:612933]. A metabolic disorder that results in exertional myoglobinuria, pain, cramps and easy fatigue.[1]

About this StructureAbout this Structure

4jnk is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

[xtra 1]

  1. ↑ Dragovich PS, Fauber BP, Corson LB, Ding CZ, Eigenbrot C, Ge H, Giannetti AM, Hunsaker T, Labadie S, Liu Y, Malek S, Pan B, Peterson D, Pitts K, Purkey HE, Sideris S, Ultsch M, Vanderporten E, Wei B, Xu Q, Yen I, Yue Q, Zhang H, Zhang X. Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3186-94. doi: 10.1016/j.bmcl.2013.04.001., Epub 2013 Apr 10. PMID:23628333 doi:10.1016/j.bmcl.2013.04.001
  1. ↑ Maekawa M, Sudo K, Kanno T, Li SS. Molecular characterization of genetic mutation in human lactate dehydrogenase-A (M) deficiency. Biochem Biophys Res Commun. 1990 Apr 30;168(2):677-82. PMID:2334430

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=4jnk&oldid=1805572"