4b04: Difference between revisions
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{{STRUCTURE_4b04| PDB=4b04 | SCENE= }} | |||
===Crystal structure of the Catalytic Domain of Human DUSP26 (C152S)=== | |||
{{ABSTRACT_PUBMED_23695260}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/DUS26_HUMAN DUS26_HUMAN]] Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK).<ref>PMID:15796912</ref> <ref>PMID:16924234</ref> <ref>PMID:17001450</ref> <ref>PMID:16581800</ref> | |||
==About this Structure== | |||
[[4b04]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B04 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023695260</ref><references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Chi, S W.]] | |||
[[Category: Kim, S J.]] | |||
[[Category: Lee, D Y.]] | |||
[[Category: Park, S G.]] | |||
[[Category: Won, E Y.]] | |||
[[Category: Yokoyama, S.]] | |||
[[Category: Hydrolase]] | |||
Revision as of 16:30, 19 June 2013
Crystal structure of the Catalytic Domain of Human DUSP26 (C152S)Crystal structure of the Catalytic Domain of Human DUSP26 (C152S)
Template:ABSTRACT PUBMED 23695260
FunctionFunction
[DUS26_HUMAN] Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK).[1] [2] [3] [4]
About this StructureAbout this Structure
4b04 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Won EY, Xie Y, Takemoto C, Chen L, Liu ZJ, Wang BC, Lee D, Woo EJ, Park SG, Shirouzu M, Yokoyama S, Kim SJ, Chi SW. High-resolution crystal structure of the catalytic domain of human dual-specificity phosphatase 26. Acta Crystallogr D Biol Crystallogr. 2013 Jun;69(Pt 6):1160-70. doi:, 10.1107/S0907444913004770. Epub 2013 May 16. PMID:23695260 doi:10.1107/S0907444913004770
- ↑ Vasudevan SA, Skoko J, Wang K, Burlingame SM, Patel PN, Lazo JS, Nuchtern JG, Yang J. MKP-8, a novel MAPK phosphatase that inhibits p38 kinase. Biochem Biophys Res Commun. 2005 May 6;330(2):511-8. PMID:15796912 doi:10.1016/j.bbrc.2005.03.028
- ↑ Yu W, Imoto I, Inoue J, Onda M, Emi M, Inazawa J. A novel amplification target, DUSP26, promotes anaplastic thyroid cancer cell growth by inhibiting p38 MAPK activity. Oncogene. 2007 Feb 22;26(8):1178-87. Epub 2006 Aug 21. PMID:16924234 doi:10.1038/sj.onc.1209899
- ↑ Takagaki K, Shima H, Tanuma N, Nomura M, Satoh T, Watanabe M, Kikuchi K. Characterization of a novel low-molecular-mass dual specificity phosphatase-4 (LDP-4) expressed in brain. Mol Cell Biochem. 2007 Feb;296(1-2):177-84. Epub 2006 Sep 26. PMID:17001450 doi:10.1007/s11010-006-9313-5
- ↑ Hu Y, Mivechi NF. Association and regulation of heat shock transcription factor 4b with both extracellular signal-regulated kinase mitogen-activated protein kinase and dual-specificity tyrosine phosphatase DUSP26. Mol Cell Biol. 2006 Apr;26(8):3282-94. PMID:16581800 doi:26/8/3282