3rbd: Difference between revisions
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{{STRUCTURE_3rbd| PDB=3rbd | SCENE= }} | {{STRUCTURE_3rbd| PDB=3rbd | SCENE= }} | ||
===Dpo4 extension ternary complex with 3'-terminal primer C base opposite the 3-methylcytosine (m3c) lesion=== | ===Dpo4 extension ternary complex with 3'-terminal primer C base opposite the 3-methylcytosine (m3c) lesion=== | ||
{{ABSTRACT_PUBMED_21645853}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/DPO4_SULSO DPO4_SULSO]] Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. It is involved in translesional synthesis.[HAMAP-Rule:MF_01113] | |||
==About this Structure== | ==About this Structure== | ||
[[3rbd]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[3rbd]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus_p2 Sulfolobus solfataricus p2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RBD OCA]. | ||
== | ==Reference== | ||
<ref group="xtra">PMID:021645853</ref><references group="xtra"/><references/> | |||
[[Category: DNA-directed DNA polymerase]] | [[Category: DNA-directed DNA polymerase]] | ||
[[Category: Sulfolobus solfataricus]] | [[Category: Sulfolobus solfataricus p2]] | ||
[[Category: Patel, D J.]] | [[Category: Patel, D J.]] | ||
[[Category: Rechkoblit, O.]] | [[Category: Rechkoblit, O.]] | ||
Revision as of 16:23, 19 June 2013
Dpo4 extension ternary complex with 3'-terminal primer C base opposite the 3-methylcytosine (m3c) lesionDpo4 extension ternary complex with 3'-terminal primer C base opposite the 3-methylcytosine (m3c) lesion
Template:ABSTRACT PUBMED 21645853
FunctionFunction
[DPO4_SULSO] Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. It is involved in translesional synthesis.[HAMAP-Rule:MF_01113]
About this StructureAbout this Structure
3rbd is a 6 chain structure with sequence from Sulfolobus solfataricus p2. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Rechkoblit O, Delaney JC, Essigmann JM, Patel DJ. Implications for damage recognition during Dpo4-mediated mutagenic bypass of m1G and m3C lesions. Structure. 2011 Jun 8;19(6):821-32. doi: 10.1016/j.str.2011.03.020. PMID:21645853 doi:10.1016/j.str.2011.03.020
Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCACategories:
- DNA-directed DNA polymerase
- Sulfolobus solfataricus p2
- Patel, D J.
- Rechkoblit, O.
- 3-methylcytosine
- Dna damage
- Dna polymerase
- Dna repair
- Dna replication
- Dna-binding
- Dna-directed dna polymerase
- Dntp-binding
- Lesion bypass
- Magnesium
- Metal-binding
- Mutator protein
- Nucleotidyltransferase
- Transferase
- Transferase-dna complex
- Y-family polymerase