2h3d: Difference between revisions
New page: left|200px<br /><applet load="2h3d" size="450" color="white" frame="true" align="right" spinBox="true" caption="2h3d, resolution 2.10Å" /> '''Crystal Structure of... |
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[[Image:2h3d.gif|left|200px]]<br /><applet load="2h3d" size=" | [[Image:2h3d.gif|left|200px]]<br /><applet load="2h3d" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="2h3d, resolution 2.10Å" /> | caption="2h3d, resolution 2.10Å" /> | ||
'''Crystal Structure of Mouse Nicotinamide Phosphoribosyltransferase/Visfatin/Pre-B Cell Colony Enhancing Factor in Complex with Nicotinamide Mononuleotide'''<br /> | '''Crystal Structure of Mouse Nicotinamide Phosphoribosyltransferase/Visfatin/Pre-B Cell Colony Enhancing Factor in Complex with Nicotinamide Mononuleotide'''<br /> | ||
==Overview== | ==Overview== | ||
Nicotinamide phosphoribosyltransferase (Nampt) synthesizes nicotinamide | Nicotinamide phosphoribosyltransferase (Nampt) synthesizes nicotinamide mononucleotide (NMN) from nicotinamide in a mammalian NAD+ biosynthetic pathway and is required for SirT1 activity in vivo. Nampt has also been presumed to be a cytokine (PBEF) or a hormone (visfatin). The crystal structure of Nampt in the presence and absence of NMN shows that Nampt is a dimeric type II phosphoribosyltransferase and provides insights into the enzymatic mechanism. | ||
==About this Structure== | ==About this Structure== | ||
2H3D is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with NMN as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Nicotinamide_phosphoribosyltransferase Nicotinamide phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.12 2.4.2.12] Full crystallographic information is available from [http:// | 2H3D is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=NMN:'>NMN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Nicotinamide_phosphoribosyltransferase Nicotinamide phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.12 2.4.2.12] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H3D OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Bheda, P.]] | [[Category: Bheda, P.]] | ||
[[Category: Imai, S | [[Category: Imai, S I.]] | ||
[[Category: Revollo, J | [[Category: Revollo, J R.]] | ||
[[Category: Wang, T.]] | [[Category: Wang, T.]] | ||
[[Category: Wolberger, C.]] | [[Category: Wolberger, C.]] | ||
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[[Category: typeii phsophoribosyltransferase]] | [[Category: typeii phsophoribosyltransferase]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:37:46 2008'' | ||
