4jkc: Difference between revisions

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-'''Unreleased structure'''
+{{STRUCTURE_4jkc|  PDB=4jkc  |  SCENE=  }}
+===Open and closed forms of T1800E human PRP8 RNase H-like domain with bound Mg ion===
+{{ABSTRACT_PUBMED_23686287}}
-The entry 4jkc is ON HOLD  until Paper Publication
+==Disease==
+[[http://www.uniprot.org/uniprot/PRP8_HUMAN PRP8_HUMAN]] Defects in PRPF8 are the cause of retinitis pigmentosa type 13 (RP13) [MIM:[http://omim.org/entry/600059 600059]]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP13 inheritance is autosomal dominant.<ref>PMID:17317632</ref> <ref>PMID:11468273</ref> [:]<ref>PMID:11910553</ref> <ref>PMID:12714658</ref>
-Authors: Schellenberg, M.J., Wu, T., Ritchie, D.B., Atta, K.A., MacMillan, A.M.
+==Function==
+[[http://www.uniprot.org/uniprot/PRP8_HUMAN PRP8_HUMAN]] Central component of the spliceosome, which may play a role in aligning the pre-mRNA 5'- and 3'-exons for ligation. Interacts with U5 snRNA, and with pre-mRNA 5'-splice sites in B spliceosomes and 3'-splice sites in C spliceosomes.
-Description: Open and closed forms of T1800E human PRP8 RNase H-like domain with bound Mg ion
+==About this Structure==
+[[4jkc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JKC OCA].
+==Reference==
+<ref group="xtra">PMID:023686287</ref><references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: Atta, K A.]]
+[[Category: MacMillan, A M.]]
+[[Category: Ritchie, D B.]]
+[[Category: Schellenberg, M J.]]
+[[Category: Wu, T.]]
+[[Category: Conformational change]]
+[[Category: Metalloprotein]]
+[[Category: Rna binding protein]]