4jgt: Difference between revisions

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-'''Unreleased structure'''
+{{STRUCTURE_4jgt|  PDB=4jgt  |  SCENE=  }}
+===Structure and kinetic analysis of H2S production by human Mercaptopyruvate Sulfurtransferase===
+{{ABSTRACT_PUBMED_23698001}}
-The entry 4jgt is ON HOLD  until Paper Publication
+==Disease==
+[[http://www.uniprot.org/uniprot/THTM_HUMAN THTM_HUMAN]] Encephalopathy due to beta-mercaptolactate-cysteine disulfiduria. Note=Aberrant MPST activity is found in a few cases of mercaptolactate-cysteine disulfiduria (MCDU) characterized by the appearance of large quantaties of the sulfur-containing amino acid, beta-mercaptolactate-cysteine disulfide, in the urine (PubMed:4973015, PubMed:4690911 and PubMed:6945862). Some cases have associated mental retardation (PubMed:4973015 and PubMed:6945862).
-Authors: Koutmos, M., Yamada, K., Yadav, P.K., Chiku, T., Banerjee, R.
+==Function==
+[[http://www.uniprot.org/uniprot/THTM_HUMAN THTM_HUMAN]] Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. Detoxifies cyanide and is required for thiosulfate biosynthesis. Acts as an antioxidant. In combination with cysteine aminotransferase (CAT), contributes to the catabolism of cysteine and is an important producer of hydrogen sulfide in the brain, retina and vascular endothelial cells. Hydrogen sulfide H(2)S is an important synaptic modulator, signaling molecule, smooth muscle contractor and neuroprotectant. Its production by the 3MST/CAT pathway is regulated by calcium ions (By similarity).
-Description: Structure and kinetic analysis of H2S production by human Mercaptopyruvate Sulfurtransferase
+==About this Structure==
+[[4jgt]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JGT OCA].
+==Reference==
+<ref group="xtra">PMID:023698001</ref><references group="xtra"/><references/>
+[[Category: 3-mercaptopyruvate sulfurtransferase]]
+[[Category: Homo sapiens]]
+[[Category: Banerjee, R.]]
+[[Category: Chiku, T.]]
+[[Category: Koutmos, M.]]
+[[Category: Yadav, P K.]]
+[[Category: Yamada, K.]]
+[[Category: Rhodanese]]
+[[Category: Transferase]]