2gtt: Difference between revisions
New page: left|200px<br /><applet load="2gtt" size="450" color="white" frame="true" align="right" spinBox="true" caption="2gtt, resolution 3.49Å" /> '''Crystal structure of... |
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[[Image:2gtt.gif|left|200px]]<br /><applet load="2gtt" size=" | [[Image:2gtt.gif|left|200px]]<br /><applet load="2gtt" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="2gtt, resolution 3.49Å" /> | caption="2gtt, resolution 3.49Å" /> | ||
'''Crystal structure of the rabies virus nucleoprotein-RNA complex'''<br /> | '''Crystal structure of the rabies virus nucleoprotein-RNA complex'''<br /> | ||
==Overview== | ==Overview== | ||
Negative-strand RNA viruses condense their genome into a helical | Negative-strand RNA viruses condense their genome into a helical nucleoprotein-RNA complex, the nucleocapsid, which is packed into virions and serves as a template for the RNA-dependent RNA polymerase complex. The crystal structure of a recombinant rabies virus nucleoprotein-RNA complex, organized in an undecameric ring, has been determined at 3.5 angstrom resolution. Polymerization of the nucleoprotein is achieved by domain exchange between protomers, with flexible hinges allowing nucleocapsid formation. The two core domains of the nucleoprotein clamp around the RNA at their interface and shield it from the environment. RNA sequestering by nucleoproteins is likely a common mechanism used by negative-strand RNA viruses to protect their genomes from the innate immune response directed against viral RNA in human host cells at certain stages of an infectious cycle. | ||
==About this Structure== | ==About this Structure== | ||
2GTT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rabies_virus Rabies virus]. Full crystallographic information is available from [http:// | 2GTT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rabies_virus Rabies virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GTT OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Rabies virus]] | [[Category: Rabies virus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Albertini, A | [[Category: Albertini, A A.V.]] | ||
[[Category: Muziol, T.]] | [[Category: Muziol, T.]] | ||
[[Category: Ravelli, R | [[Category: Ravelli, R B.G.]] | ||
[[Category: Ruigrok, R | [[Category: Ruigrok, R W.H.]] | ||
[[Category: Weissenhorn, W.]] | [[Category: Weissenhorn, W.]] | ||
[[Category: Wernimont, A | [[Category: Wernimont, A K.]] | ||
[[Category: nucleoprotein]] | [[Category: nucleoprotein]] | ||
[[Category: protein-rna complex]] | [[Category: protein-rna complex]] | ||
[[Category: rabies virus]] | [[Category: rabies virus]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:35:17 2008'' | ||
Revision as of 18:35, 21 February 2008
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Crystal structure of the rabies virus nucleoprotein-RNA complex
OverviewOverview
Negative-strand RNA viruses condense their genome into a helical nucleoprotein-RNA complex, the nucleocapsid, which is packed into virions and serves as a template for the RNA-dependent RNA polymerase complex. The crystal structure of a recombinant rabies virus nucleoprotein-RNA complex, organized in an undecameric ring, has been determined at 3.5 angstrom resolution. Polymerization of the nucleoprotein is achieved by domain exchange between protomers, with flexible hinges allowing nucleocapsid formation. The two core domains of the nucleoprotein clamp around the RNA at their interface and shield it from the environment. RNA sequestering by nucleoproteins is likely a common mechanism used by negative-strand RNA viruses to protect their genomes from the innate immune response directed against viral RNA in human host cells at certain stages of an infectious cycle.
About this StructureAbout this Structure
2GTT is a Single protein structure of sequence from Rabies virus. Full crystallographic information is available from OCA.
ReferenceReference
Crystal structure of the rabies virus nucleoprotein-RNA complex., Albertini AA, Wernimont AK, Muziol T, Ravelli RB, Clapier CR, Schoehn G, Weissenhorn W, Ruigrok RW, Science. 2006 Jul 21;313(5785):360-3. Epub 2006 Jun 15. PMID:16778023
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