3ran: Difference between revisions
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{{STRUCTURE_3ran| PDB=3ran | SCENE= }} | {{STRUCTURE_3ran| PDB=3ran | SCENE= }} | ||
===CANINE GDP-RAN Q69L MUTANT=== | ===CANINE GDP-RAN Q69L MUTANT=== | ||
{{ABSTRACT_PUBMED_9878368}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/RAN_CANFA RAN_CANFA]] GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2 (By similarity). | |||
==About this Structure== | ==About this Structure== | ||
[[3ran]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RAN OCA]. | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:009878368</ref><references group="xtra"/><references/> | ||
[[Category: Canis lupus familiaris]] | [[Category: Canis lupus familiaris]] | ||
[[Category: Kent, H M.]] | [[Category: Kent, H M.]] | ||
| Line 30: | Line 17: | ||
[[Category: Gtpase]] | [[Category: Gtpase]] | ||
[[Category: Nuclear transport]] | [[Category: Nuclear transport]] | ||
[[Category: Transport protein]] | |||
Revision as of 10:42, 16 May 2013
CANINE GDP-RAN Q69L MUTANTCANINE GDP-RAN Q69L MUTANT
Template:ABSTRACT PUBMED 9878368
FunctionFunction
[RAN_CANFA] GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2 (By similarity).
About this StructureAbout this Structure
3ran is a 4 chain structure with sequence from Canis lupus familiaris. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Stewart M, Kent HM, McCoy AJ. The structure of the Q69L mutant of GDP-Ran shows a major conformational change in the switch II loop that accounts for its failure to bind nuclear transport factor 2 (NTF2). J Mol Biol. 1998 Dec 18;284(5):1517-27. PMID:9878368 doi:10.1006/jmbi.1998.2204