SB2013 L04gr5: Difference between revisions
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Vmp-like sequence Expressed protein (VlsE), is a [http://en.wikipedia.org/wiki/Lipoprotein lipoprotein] on the surface of Borrelia burgdorferi. VlsE contributes to the immune evasion and persistence of Lyme disease.<ref name="Coutte" /> VlsE contains invaraible and varaible domains. It was found that the varaible domain is highly immunogenic and the target of the immune response; however, through [http://en.wikipedia.org/wiki/Antigenic_variation antigenic variation] the lipoprotein is able to evade the host immune system.<ref name="Liang" /> | Vmp-like sequence Expressed protein (VlsE), is a [http://en.wikipedia.org/wiki/Lipoprotein lipoprotein] on the surface of Borrelia burgdorferi. VlsE contributes to the immune evasion and persistence of Lyme disease.<ref name="Coutte" /> VlsE contains invaraible and varaible domains. It was found that the varaible domain is highly immunogenic and the target of the immune response; however, through [http://en.wikipedia.org/wiki/Antigenic_variation antigenic variation] the lipoprotein is able to evade the host immune system.<ref name="Liang" /> | ||
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Within the varible domain there are invariable regions that remain unchanged during antigenic varaition, and therefore may be targets of an immune response. IR6, the most conserved IR, has been found to be immnodominant. The antigencity of each of the 6 IRs have been studied using peptide-based enzyme linked immunosorbent essays,[http://en.wikipedia.org/wiki/ELISA ELISA].<ref name="Liang" /> | Within the varible domain there are invariable regions that remain unchanged during antigenic varaition, and therefore may be targets of an immune response. IR6, the most conserved IR, has been found to be immnodominant. The antigencity of each of the 6 IRs have been studied using peptide-based enzyme linked immunosorbent essays,[http://en.wikipedia.org/wiki/ELISA ELISA].<ref name="Liang" /> | ||