HDim1/U5-15kD: Difference between revisions
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<Structure load='1qgv' size='300' frame='true' align='left' caption='Figure 1: ' scene='Sandbox_502/Hdim1_start_scene/2'/> | |||
== Structure of the hDim1/U5-15kD Protein == | == Structure of the hDim1/U5-15kD Protein == | ||
by Kelly Hrywkiw | by Kelly Hrywkiw | ||
__TOC__ | __TOC__ | ||
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==Oxidized Full Length Form (hDim1)== | ==Oxidized Full Length Form (hDim1)== | ||
The thioredoxin-like fold of <scene name='Sandbox_502/Hdim1_start_scene/2'>hDim1</scene> follows the arrangement of a five stranded β-sheet, consisting of parallel and antiparallel stands, surrounded by three α-helices, where the loop between β4 and α3 could not be resolved. When compared to human thioredoxin there are a total of 37 additional residues in hDim1, which result in several structural differences. For example, the N-terminus is extended by three residues, in the α2-β2 loop one residue is inserted, after β4 nine are inserted, before the α2 helix two are inserted, and <scene name='Sandbox_502/Hdim1_c-terminal_extension/1'>22 extend the C-terminus</scene>. This results in an altered structure where β4 and β5 appear to be pulled away from the β-sheet leaving a <scene name='Sandbox_502/Hdim1cleft/1'>cleft</scene> between β3 and β4<ref name ="Reuter"/>. | The thioredoxin-like fold of <scene name='Sandbox_502/Hdim1_start_scene/2'>hDim1</scene> follows the arrangement of a five stranded β-sheet, consisting of parallel and antiparallel stands, surrounded by three α-helices, where the loop between β4 and α3 could not be resolved. When compared to human thioredoxin there are a total of 37 additional residues in hDim1, which result in several structural differences. For example, the N-terminus is extended by three residues, in the α2-β2 loop one residue is inserted, after β4 nine are inserted, before the α2 helix two are inserted, and <scene name='Sandbox_502/Hdim1_c-terminal_extension/1'>22 extend the C-terminus</scene>. This results in an altered structure where β4 and β5 appear to be pulled away from the β-sheet leaving a <scene name='Sandbox_502/Hdim1cleft/1'>cleft</scene> between β3 and β4<ref name ="Reuter"/>. | ||