3q0h: Difference between revisions

Revision as of 11:28, 8 May 2013

Structure of T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT)Structure of T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT)

FunctionFunction

[TIGIT_HUMAN] Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.

About this StructureAbout this Structure

3q0h is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 {{STRUCTURE_3q0h|  PDB=3q0h  |  SCENE=  }}
 ===Structure of T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT)===
+==Function==
+[[http://www.uniprot.org/uniprot/TIGIT_HUMAN TIGIT_HUMAN]] Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.
 ==About this Structure==
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 [[Category: Ramagopal, U A.]]
 [[Category: Samanta, D.]]
+[[Category: Adhesion]]
+[[Category: Immune receptor]]
+[[Category: Immune system]]
+[[Category: New york structural genomics research consortium]]
+[[Category: Nysgrc]]
+[[Category: Psi-biology]]
+[[Category: Structural genomic]]