2xhl: Difference between revisions
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{{STRUCTURE_2xhl| PDB=2xhl | SCENE= }} | {{STRUCTURE_2xhl| PDB=2xhl | SCENE= }} | ||
===STRUCTURE OF A FUNCTIONAL DERIVATIVE OF CLOSTRIDIUM BOTULINUM NEUROTOXIN TYPE B=== | ===STRUCTURE OF A FUNCTIONAL DERIVATIVE OF CLOSTRIDIUM BOTULINUM NEUROTOXIN TYPE B=== | ||
{{ABSTRACT_PUBMED_21078393}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/BXB_CLOBO BXB_CLOBO]] Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that cleaves the '76-Gln-|-Phe-77' bond of synaptobrevin-2. | |||
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==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:021078393</ref><references group="xtra"/> | <ref group="xtra">PMID:021078393</ref><references group="xtra"/><references/> | ||
[[Category: Bontoxilysin]] | [[Category: Bontoxilysin]] | ||
[[Category: Clostridium botulinum]] | [[Category: Clostridium botulinum]] | ||
Revision as of 11:26, 8 May 2013
STRUCTURE OF A FUNCTIONAL DERIVATIVE OF CLOSTRIDIUM BOTULINUM NEUROTOXIN TYPE BSTRUCTURE OF A FUNCTIONAL DERIVATIVE OF CLOSTRIDIUM BOTULINUM NEUROTOXIN TYPE B
Template:ABSTRACT PUBMED 21078393
FunctionFunction
[BXB_CLOBO] Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that cleaves the '76-Gln-|-Phe-77' bond of synaptobrevin-2.
About this StructureAbout this Structure
2xhl is a 2 chain structure with sequence from Clostridium botulinum. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Masuyer G, Beard M, Cadd VA, Chaddock JA, Acharya KR. Structure and activity of a functional derivative of Clostridium botulinum neurotoxin B. J Struct Biol. 2010 Nov 13. PMID:21078393 doi:10.1016/j.jsb.2010.11.010