2gcu: Difference between revisions
New page: left|200px<br /><applet load="2gcu" size="450" color="white" frame="true" align="right" spinBox="true" caption="2gcu, resolution 1.477Å" /> '''X-Ray Structure of ... |
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[[Image:2gcu.gif|left|200px]]<br /><applet load="2gcu" size=" | [[Image:2gcu.gif|left|200px]]<br /><applet load="2gcu" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="2gcu, resolution 1.477Å" /> | caption="2gcu, resolution 1.477Å" /> | ||
'''X-Ray Structure of Gene Product from Arabidopsis Thaliana At1g53580'''<br /> | '''X-Ray Structure of Gene Product from Arabidopsis Thaliana At1g53580'''<br /> | ||
==Overview== | ==Overview== | ||
The protein product of gene At1g53580 from Arabidopsis thaliana possesses | The protein product of gene At1g53580 from Arabidopsis thaliana possesses 54% sequence identity to a human enzyme that has been implicated in the rare disorder ethylmalonic encephalopathy. The structure of the At1g53580 protein has been solved to a nominal resolution of 1.48 Angstrom. This structure reveals tertiary structure differences between the ETHE1-like enzyme and glyoxalase II enzymes that are likely to account for differences in reaction chemistry and multimeric state between the two types of enzymes. In addition, the Arabidopsis ETHE1 protein is used as a model to explain the significance of several mutations in the human enzyme that have been observed in patients with ethylmalonic encephalopathy. | ||
==About this Structure== | ==About this Structure== | ||
2GCU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana] with FE2, SO4 and EDO as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Hydroxyacylglutathione_hydrolase Hydroxyacylglutathione hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.2.6 3.1.2.6] Full crystallographic information is available from [http:// | 2GCU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana] with <scene name='pdbligand=FE2:'>FE2</scene>, <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=EDO:'>EDO</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Hydroxyacylglutathione_hydrolase Hydroxyacylglutathione hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.2.6 3.1.2.6] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GCU OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Hydroxyacylglutathione hydrolase]] | [[Category: Hydroxyacylglutathione hydrolase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Bingman, C | [[Category: Bingman, C A.]] | ||
[[Category: Bitto, E.]] | [[Category: Bitto, E.]] | ||
[[Category: CESG, Center | [[Category: CESG, Center for Eukaryotic Structural Genomics.]] | ||
[[Category: Jr., G | [[Category: Jr., G N.Phillips.]] | ||
[[Category: McCoy, J | [[Category: McCoy, J G.]] | ||
[[Category: Wesenberg, G | [[Category: Wesenberg, G E.]] | ||
[[Category: EDO]] | [[Category: EDO]] | ||
[[Category: FE2]] | [[Category: FE2]] | ||
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[[Category: structural genomics]] | [[Category: structural genomics]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:30:26 2008'' | ||
Revision as of 18:30, 21 February 2008
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X-Ray Structure of Gene Product from Arabidopsis Thaliana At1g53580
OverviewOverview
The protein product of gene At1g53580 from Arabidopsis thaliana possesses 54% sequence identity to a human enzyme that has been implicated in the rare disorder ethylmalonic encephalopathy. The structure of the At1g53580 protein has been solved to a nominal resolution of 1.48 Angstrom. This structure reveals tertiary structure differences between the ETHE1-like enzyme and glyoxalase II enzymes that are likely to account for differences in reaction chemistry and multimeric state between the two types of enzymes. In addition, the Arabidopsis ETHE1 protein is used as a model to explain the significance of several mutations in the human enzyme that have been observed in patients with ethylmalonic encephalopathy.
About this StructureAbout this Structure
2GCU is a Single protein structure of sequence from Arabidopsis thaliana with , and as ligands. Active as Hydroxyacylglutathione hydrolase, with EC number 3.1.2.6 Full crystallographic information is available from OCA.
ReferenceReference
Structure of an ETHE1-like protein from Arabidopsis thaliana., McCoy JG, Bingman CA, Bitto E, Holdorf MM, Makaroff CA, Phillips GN Jr, Acta Crystallogr D Biol Crystallogr. 2006 Sep;62(Pt 9):964-70. Epub 2006, Aug 19. PMID:16929096
Page seeded by OCA on Thu Feb 21 17:30:26 2008
Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCA- Pages with broken file links
- Arabidopsis thaliana
- Hydroxyacylglutathione hydrolase
- Single protein
- Bingman, C A.
- Bitto, E.
- CESG, Center for Eukaryotic Structural Genomics.
- Jr., G N.Phillips.
- McCoy, J G.
- Wesenberg, G E.
- EDO
- FE2
- SO4
- Center for eukaryotic structural genomics
- Cesg
- Ethe1
- Ethylmalonic encephalopathy
- Protein structure initiative
- Psi
- Structural genomics