3qk5: Difference between revisions
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{{STRUCTURE_3qk5| PDB=3qk5 | SCENE= }} | {{STRUCTURE_3qk5| PDB=3qk5 | SCENE= }} | ||
===Crystal structure of fatty acid amide hydrolase with small molecule inhibitor=== | ===Crystal structure of fatty acid amide hydrolase with small molecule inhibitor=== | ||
{{ABSTRACT_PUBMED_21392988}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/FAAH1_RAT FAAH1_RAT]] Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (By similarity). | |||
==About this Structure== | ==About this Structure== | ||
| Line 22: | Line 10: | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:021392988</ref><references group="xtra"/><references/> | ||
[[Category: Fatty acid amide hydrolase]] | [[Category: Fatty acid amide hydrolase]] | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
| Line 28: | Line 16: | ||
[[Category: Walker, N P.C.]] | [[Category: Walker, N P.C.]] | ||
[[Category: Wang, Z.]] | [[Category: Wang, Z.]] | ||
[[Category: Faah]] | |||
[[Category: Fatty-acid amide hydrolase]] | |||
[[Category: Hydrolase-hydrolase inhibitor complex]] | |||
[[Category: Protein-inhibitor complex]] | |||
Revision as of 11:19, 8 May 2013
Crystal structure of fatty acid amide hydrolase with small molecule inhibitorCrystal structure of fatty acid amide hydrolase with small molecule inhibitor
Template:ABSTRACT PUBMED 21392988
FunctionFunction
[FAAH1_RAT] Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (By similarity).
About this StructureAbout this Structure
3qk5 is a 2 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Gustin DJ, Ma Z, Min X, Li Y, Hedberg C, Guimaraes C, Porter AC, Lindstrom M, Lester-Zeiner D, Xu G, Carlson TJ, Xiao S, Meleza C, Connors R, Wang Z, Kayser F. Identification of potent, noncovalent fatty acid amide hydrolase (FAAH) inhibitors. Bioorg Med Chem Lett. 2011 Apr 15;21(8):2492-6. Epub 2011 Feb 17. PMID:21392988 doi:10.1016/j.bmcl.2011.02.052