4jr2: Difference between revisions
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{{STRUCTURE_4jr2| PDB=4jr2 | SCENE= }} | |||
===Human procaspase-7/caspase-7 heterodimer bound to Ac-DEVD-CMK=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CASP7_HUMAN CASP7_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death. | |||
==About this Structure== | |||
[[4jr2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JR2 OCA]. | |||
[[Category: Caspase-7]] | |||
[[Category: Homo sapiens]] | |||
[[Category: Thomsen, N D.]] | |||
[[Category: Wells, J A.]] | |||
[[Category: Activity based probe]] | |||
[[Category: Apoptosis]] | |||
[[Category: Caspase]] | |||
[[Category: Hydrolase-hydrolase inhibitor complex]] | |||
[[Category: Irreversible inhibitor]] | |||
[[Category: Proenzyme]] | |||
[[Category: Protease]] | |||
[[Category: Protein-peptide complex]] | |||
Revision as of 10:56, 8 May 2013
Human procaspase-7/caspase-7 heterodimer bound to Ac-DEVD-CMKHuman procaspase-7/caspase-7 heterodimer bound to Ac-DEVD-CMK
FunctionFunction
[CASP7_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.
About this StructureAbout this Structure
4jr2 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.