4jr5: Difference between revisions

Revision as of 10:43, 8 May 2013

Structure-based Identification of Ureas as Novel Nicotinamide Phosphoribosyltransferase (Nampt) InhibitorsStructure-based Identification of Ureas as Novel Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors

FunctionFunction

[NAMPT_HUMAN] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).

About this StructureAbout this Structure

4jr5 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4jr5|  PDB=4jr5  |  SCENE=  }}
+===Structure-based Identification of Ureas as Novel Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors===
+{{ABSTRACT_PUBMED_23617784}}
-The entry 4jr5 is ON HOLD
+==Function==
+[[http://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN]] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).
-Authors: Zheng, X., Bauer, P., Baumeister, T., Buckmelter, A.J., Caligiuri, M., Clodfelter, K.H., Han, B., Ho, Y., Kley, N., Lin, J., Reynolds, D.J., Sharma, G., Smith, C.C., Wang, Z., Dragovich, P.S., Oh, A., Wang, W., Zak, M., Gunzner-Toste, J., Zhao, G., Yuen, P., Bair, K.W.
+==About this Structure==
+[[4jr5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JR5 OCA].
-Description: Structure-based Identification of Ureas as Novel Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors
+[[Category: Homo sapiens]]
+[[Category: Nicotinamide phosphoribosyltransferase]]
+[[Category: Bair, K W.]]
+[[Category: Bauer, P.]]
+[[Category: Baumeister, T.]]
+[[Category: Buckmelter, A J.]]
+[[Category: Caligiuri, M.]]
+[[Category: Clodfelter, K H.]]
+[[Category: Dragovich, P S.]]
+[[Category: Gunzner-Toste, J.]]
+[[Category: Han, B.]]
+[[Category: Ho, Y.]]
+[[Category: Kley, N.]]
+[[Category: Lin, J.]]
+[[Category: Oh, A.]]
+[[Category: Reynolds, D J.]]
+[[Category: Sharma, G.]]
+[[Category: Smith, C C.]]
+[[Category: Wang, W.]]
+[[Category: Wang, Z.]]
+[[Category: Yuen, P.]]
+[[Category: Zak, M.]]
+[[Category: Zhao, G.]]
+[[Category: Zheng, X.]]
+[[Category: Transferase-transferase inhibitor complex]]