G1SecL05: Difference between revisions
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===Ala-208=== | ===Ala-208=== | ||
In ''B. burgdorferi'', residue 208 expresses Alanine, whereas in ''B. afzelii'', and ''B. garinii'', Glutamine is expressed. The variation in this residue is another factor, which inhibits successful antibody cross-reactivity between other strains of ''Borrelia''. LA-2 and OspA of ''B. burgdorferi'' forms a tight border when binding and this is promoted by the Alanine 208 residue. The Glutamine residue that is found in ''B. afzelii'' and ''B. garinii'' is longer and more problematic when it comes to binding<ref name = "interactions"/>. It creates a looser, more ineffective interface between the LA-2 and OspA, which conclusively makes an ineffectual vaccine. | In ''B. burgdorferi'', residue 208 expresses Alanine, whereas in ''B. afzelii'', and ''B. garinii'', Glutamine is expressed. The variation in this "first loop" residue is another factor, which inhibits successful antibody cross-reactivity between other strains of ''Borrelia''. LA-2 and OspA of ''B. burgdorferi'' forms a tight border when binding and this is promoted by the Alanine 208 residue. The Glutamine residue that is found in ''B. afzelii'' and ''B. garinii'' is longer and more problematic when it comes to binding<ref name = "interactions"/>. It creates a looser, more ineffective interface between the LA-2 and OspA, which conclusively makes an ineffectual vaccine. | ||
===Residues 217-237=== | ===Residues 217-237=== | ||