G1SecL05: Difference between revisions
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== | =='''OspA + LA-2 Complex'''== | ||
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==Background== | ==Background== | ||
[http://en.wikipedia.org/wiki/Lyme_disease Lyme disease], discovered in 1975<ref>PMID: 17160599</ref>, is a vector--borne disease caused by the inoculation of a [http://en.wikipedia.org/wiki/Spirochaete spirochaete], specifically ''[http://en.wikipedia.org/wiki/Borrelia_burgdorferi Borellia burgdorferi]'', into the skin by members of hard bodied ticks of the family ''[http://en.wikipedia.org/wiki/ Ixodes]''. Symptoms include arthritis at major joints, neurological problems such as reduced memory and poor ability to concentrate, and characteristic lesions ''erythema migans'', more commonly known as the bull’s eye rash. A major outer surface membrane protein of ''Borrelia'', ospA, plays a key role in immunity against Lyme disease through its binding to the LA-2 [http://en.wikipedia.org/wiki/Fragment_antigen-binding fab]. The Fragment Antigen Binding (fab) consists of a [http://en.wikipedia.org/wiki/Immunoglobulin_heavy_chain heavy chain] and [http://en.wikipedia.org/wiki/Immunoglobulin_light_chain light chain], with each respective region having its own constant and variable regions. | [http://en.wikipedia.org/wiki/Lyme_disease Lyme disease], discovered in 1975<ref>PMID: 17160599</ref>, is a vector--borne disease caused by the inoculation of a [http://en.wikipedia.org/wiki/Spirochaete spirochaete], specifically ''[http://en.wikipedia.org/wiki/Borrelia_burgdorferi Borellia burgdorferi]'', into the skin by members of hard bodied ticks of the family ''[http://en.wikipedia.org/wiki/ Ixodes]''. Symptoms include arthritis at major joints, neurological problems such as reduced memory and poor ability to concentrate, and characteristic lesions ''erythema migans'', more commonly known as the bull’s eye rash. A major outer surface membrane protein of ''Borrelia'', ospA, plays a key role in immunity against Lyme disease through its binding to the LA-2 [http://en.wikipedia.org/wiki/Fragment_antigen-binding fab]. The Fragment Antigen Binding (fab) consists of a [http://en.wikipedia.org/wiki/Immunoglobulin_heavy_chain heavy chain] and [http://en.wikipedia.org/wiki/Immunoglobulin_light_chain light chain], with each respective region having its own constant and variable regions. | ||