Complement Regulator-Acquiring Surface Protein: Difference between revisions

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Kerry Brathwaite, Dipanshu Walia, Michal Harel, Kwangsun Yoo, Jaime Prilusky, Alexander Berchansky

Revision as of 06:46, 6 May 2013 view source Kerry Brathwaite (talk \| contribs) 49 edits No edit summary ← Older edit		Revision as of 07:15, 6 May 2013 view source Kerry Brathwaite (talk \| contribs) 49 edits No edit summary Newer edit →
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	=== '''Other Potential Binding Sites''' ===		=== '''Other Potential Binding Sites''' ===

	Additional studies were done to investigate the FH and FHL-1 binding sites on the protein. As with previous research, areas of high conservation were investigated due to their relationship with upholding the structure and function of the protein <ref name="CordesF">PMID: 16530476</ref>. Researchers examined highly conserved areas of amino acid sequences ~~along~~ the <scene name='SB2013_L01gr6/Pocket_region/3'>cleft region</scene> of the protein. ~~They saw that the majority of these regions clustered on a highly-exposed region of the protein.~~ A binding site in this region would be probable because this area allows more contact with the regulator proteins and would aid in further evasion of the immune system by shielding the binding domain from potential detection <ref name="CordesF">PMID: 16530476</ref>.		Additional studies were done to investigate the FH and FHL-1 binding sites on the protein. As with previous research, areas of high conservation were investigated due to their relationship with upholding the structure and function of the protein <ref name="CordesF">PMID: 16530476</ref>. Researchers examined highly conserved areas of amino acid sequences among various Borrelia CRASP-1 proteins encoded by the same gene. They saw that the greatest homologous region was clustered on the center of the <scene name='SB2013_L01gr6/Pocket_region/3'>cleft region</scene> of the protein. A binding site in this region would be probable because this area allows more contact with the regulator proteins and would aid in further evasion of the immune system by shielding the binding domain from potential detection <ref name="CordesF">PMID: 16530476</ref>.