Fibroblast growth factor receptor: Difference between revisions

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Michal Harel, Alexander Berchansky

Revision as of 14:49, 5 May 2013 view source Michal Harel (talk \| contribs) 31,761 edits New page: {{STRUCTURE_1evt\| PDB=1evt \| SIZE=400\| SCENE= \|right\|CAPTION= RHuman fibroblast growth factor receptor 1 ligand-binding domain modules D2 and D3 complex with fibroblast growth factor 1, ...		Revision as of 14:52, 5 May 2013 view source Michal Harel (talk \| contribs) 31,761 edits No edit summary Newer edit →
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	{{STRUCTURE_1evt\| PDB=1evt \| SIZE=400\| SCENE= \|right\|CAPTION= ~~RHuman~~ fibroblast growth factor receptor 1 ligand-binding domain modules D2 and D3 complex with fibroblast growth factor 1, [[1evt]] }}		{{STRUCTURE_1evt\| PDB=1evt \| SIZE=400\| SCENE= \|right\|CAPTION= Human fibroblast growth factor receptor 1 ligand-binding domain modules D2 and D3 (pink and yellow) complex with fibroblast growth factor 1 (grey and green), [[1evt]] }}

	'''Fibroblast growth factor receptors''' (FGFR) are receptors which bind fibroblast growth factors (FGF). FGFR consist of an extracellular ligand-binding domain (LBD), transmembrane helix domain and cytoplasmic tyrosine kinase activity domain (TKD) with phosphorylated tyrosine designated PTR. FGFR LBD contains 3 immunoglobulin-like domains D1, D2 and D3. Each FGFR can activate several FGFs. Five FGFRs have been identified so far. FGFRs differ in their ligand specificity and tissue distribution. The binding of FGF to FGFR starts a cascade of signaling which influences mitogenesis and differentiation.		'''Fibroblast growth factor receptors''' (FGFR) are receptors which bind fibroblast growth factors (FGF). FGFR consist of an extracellular ligand-binding domain (LBD), transmembrane helix domain and cytoplasmic tyrosine kinase activity domain (TKD) with phosphorylated tyrosine designated PTR. FGFR LBD contains 3 immunoglobulin-like domains D1, D2 and D3. Each FGFR can activate several FGFs. Five FGFRs have been identified so far. FGFRs differ in their ligand specificity and tissue distribution. The binding of FGF to FGFR starts a cascade of signaling which influences mitogenesis and differentiation.