Complement Regulator-Acquiring Surface Protein: Difference between revisions

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Kerry Brathwaite, Dipanshu Walia, Michal Harel, Kwangsun Yoo, Jaime Prilusky, Alexander Berchansky

Revision as of 05:02, 5 May 2013 view source Dipanshu Walia (talk \| contribs) 44 edits No edit summary ← Older edit		Revision as of 05:02, 5 May 2013 view source Dipanshu Walia (talk \| contribs) 44 edits No edit summary Newer edit →
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	=== '''Relation to the Extra Cellular Matrix''' ===		=== '''Relation to the Extra Cellular Matrix''' ===

	Recently it was found that BbCRASP-1 not only binds to FH and FHL-1 proteins, but it also binds to several other human ligands such as [http://www.uniprot.org/uniprot/BMP2_HUMAN BMP-2] and Extra cellular matrix ligands Collagen I, Collagen III, Collagen IV, fibronectin, laminin, and plasminogen <ref name"Hallstrom">PMID: 20565259</ref>. As a result of this new finding, BbCRASP-1 is said to advocate the bypassing of the complementary immune system in addition to the pathogenesis of Lyme disease. BbCRASP-1 facilitates binding of “Borrelia burgdoferi” to human cells and tissues, which helps spread the infection (Hallstrom ~~et al. 2010)~~.		Recently it was found that BbCRASP-1 not only binds to FH and FHL-1 proteins, but it also binds to several other human ligands such as [http://www.uniprot.org/uniprot/BMP2_HUMAN BMP-2] and Extra cellular matrix ligands Collagen I, Collagen III, Collagen IV, fibronectin, laminin, and plasminogen <ref name"Hallstrom">PMID: 20565259</ref>. As a result of this new finding, BbCRASP-1 is said to advocate the bypassing of the complementary immune system in addition to the pathogenesis of Lyme disease. BbCRASP-1 facilitates binding of “Borrelia burgdoferi” to human cells and tissues, which helps spread the infection <ref name"Hallstrom">PMID: 20565259</ref>.