G1SecL05: Difference between revisions
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[[Image:1FJ1 Chain E.jpg|300px|right|thumb| 1FJ1 Chain E]] | [[Image:1FJ1 Chain E.jpg|300px|right|thumb| 1FJ1 Chain E]] | ||
<Structure load='1fj1' size='500' frame='true' align='right' caption='3D Jmol model' scene='Insert optional scene name here' /> | |||
<Structure load='1fj1' size='500' frame='true' align='right' caption='3D Jmol model' | |||
scene='Insert optional scene name here' /> | |||
==Limitations == | ==Limitations == | ||
Although the LA-2- ospA complex induces a high reactivity of protective immune response for ''B. burgdorferi'', it lacks the broad specificity to encompass other genospecies of ''Borrelia''. In North America, Lyme borreliosis is caused by a single strain ''B.burgdorferi'', whereas in parts of Europe and Asia, a minimum of three strains, ''B. afzelli'', ''B. burgdorferi'', and ''B. garinii'' are involved in infecting humans<ref>PMID: 21217174</ref>. The lack of broad specificity in the LA-2- OspA complex is due to the presence of highly variable regions in ospA. | Although the LA-2- ospA complex induces a high reactivity of protective immune response for ''B. burgdorferi'', it lacks the broad specificity to encompass other genospecies of ''Borrelia''. In North America, Lyme borreliosis is caused by a single strain ''B.burgdorferi'', whereas in parts of Europe and Asia, a minimum of three strains, ''B. afzelli'', ''B. burgdorferi'', and ''B. garinii'' are involved in infecting humans<ref>PMID: 21217174</ref>. The lack of broad specificity in the LA-2- OspA complex is due to the presence of highly variable regions in ospA. | ||
===Trp -216=== | ===Trp -216=== | ||
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===Residues 217-237=== | ===Residues 217-237=== | ||
<scene name='G1SecL05/1fj1-condensed/1'>Composite Three variable regions highlights, Tryptophan 216 - Blue, Alanine 208 - Purple, Highly Variable LA-2 Fab + OspA conjunction - Red</scene> | |||