3b0f: Difference between revisions
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{{STRUCTURE_3b0f| PDB=3b0f | SCENE= }} | {{STRUCTURE_3b0f| PDB=3b0f | SCENE= }} | ||
===Crystal structure of the UBA domain of p62 and its interaction with ubiquitin=== | ===Crystal structure of the UBA domain of p62 and its interaction with ubiquitin=== | ||
{{ABSTRACT_PUBMED_021715324}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/SQSTM_MOUSE SQSTM_MOUSE]] Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures). Links ALIS to the autophagic machinery via direct interaction with MAP1 LC3 family members. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Adapter that mediates the interaction between TRAF6 and CYLD.<ref>PMID:14960283</ref> <ref>PMID:18382763</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[3b0f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B0F OCA]. | [[3b0f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B0F OCA]. | ||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Arita, K.]] | [[Category: Arita, K.]] | ||
Revision as of 11:35, 2 May 2013
Crystal structure of the UBA domain of p62 and its interaction with ubiquitinCrystal structure of the UBA domain of p62 and its interaction with ubiquitin
Template:ABSTRACT PUBMED 021715324
FunctionFunction
[SQSTM_MOUSE] Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures). Links ALIS to the autophagic machinery via direct interaction with MAP1 LC3 family members. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Adapter that mediates the interaction between TRAF6 and CYLD.[1] [2]
About this StructureAbout this Structure
3b0f is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Duran A, Serrano M, Leitges M, Flores JM, Picard S, Brown JP, Moscat J, Diaz-Meco MT. The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis. Dev Cell. 2004 Feb;6(2):303-9. PMID:14960283
- ↑ Jin W, Chang M, Paul EM, Babu G, Lee AJ, Reiley W, Wright A, Zhang M, You J, Sun SC. Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice. J Clin Invest. 2008 May;118(5):1858-66. doi: 10.1172/JCI34257. PMID:18382763 doi:10.1172/JCI34257