3ouy: Difference between revisions
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Revision as of 11:34, 2 May 2013
How the CCA-adding Enzyme Selects Adenine Over Cytosine at Position 76 of tRNAHow the CCA-adding Enzyme Selects Adenine Over Cytosine at Position 76 of tRNA
Template:ABSTRACT PUBMED 21071662
FunctionFunction
[CCA_ARCFU] Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.[1]
About this StructureAbout this Structure
3ouy is a 4 chain structure with sequence from Archaeoglobus fulgidus. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Pan B, Xiong Y, Steitz TA. How the CCA-adding enzyme selects adenine over cytosine at position 76 of tRNA. Science. 2010 Nov 12;330(6006):937-40. PMID:21071662 doi:10.1126/science.1194985
- ↑ Okabe M, Tomita K, Ishitani R, Ishii R, Takeuchi N, Arisaka F, Nureki O, Yokoyama S. Divergent evolutions of trinucleotide polymerization revealed by an archaeal CCA-adding enzyme structure. EMBO J. 2003 Nov 3;22(21):5918-27. PMID:14592988 doi:http://dx.doi.org/10.1093/emboj/cdg563