2fom: Difference between revisions
New page: left|200px<br /><applet load="2fom" size="350" color="white" frame="true" align="right" spinBox="true" caption="2fom, resolution 1.50Å" /> '''Dengue Virus NS2B/NS... |
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==Overview== | ==Overview== | ||
The replication of flaviviruses requires the correct processing of their | The replication of flaviviruses requires the correct processing of their polyprotein by the viral NS3 protease (NS3pro). Essential for the activation of NS3pro is a 47-residue region of NS2B. Here we report the crystal structures of a dengue NS2B-NS3pro complex and a West Nile virus NS2B-NS3pro complex with a substrate-based inhibitor. These structures identify key residues for NS3pro substrate recognition and clarify the mechanism of NS3pro activation. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Flavivirin]] | [[Category: Flavivirin]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Arcy, A | [[Category: Arcy, A D.]] | ||
[[Category: Erbel, P.]] | [[Category: Erbel, P.]] | ||
[[Category: Kroemer, M.]] | [[Category: Kroemer, M.]] | ||
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[[Category: ns3 protease]] | [[Category: ns3 protease]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:23:36 2008'' | ||
