2fk9: Difference between revisions
New page: left|200px<br /><applet load="2fk9" size="350" color="white" frame="true" align="right" spinBox="true" caption="2fk9, resolution 1.75Å" /> '''Human protein kinase... |
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==Overview== | ==Overview== | ||
Protein kinase C eta (PKCeta) is one of several PKC isoforms found in | Protein kinase C eta (PKCeta) is one of several PKC isoforms found in humans. It is a novel PKC isoform in that it is activated by diacylglycerol and anionic phospholipids but not calcium. The crystal structure of the PKCeta-C2 domain, which is thought to mediate anionic phospholipid sensing in the protein, was determined at 1.75 A resolution. The structure is similar to that of the PKC epsilon C2 domain but with significant variations at the putative lipid-binding site. Two serine residues within PKC eta were identified in vitro as potential autophosphorylation sites. In the unphosphorylated structure both serines line the putative lipid-binding site and may therefore play a role in the lipid-regulation of the kinase. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Dhe-Paganon, S.]] | [[Category: Dhe-Paganon, S.]] | ||
[[Category: Edwards, A.]] | [[Category: Edwards, A.]] | ||
[[Category: Jr., P | [[Category: Jr., P J.Finerty.]] | ||
[[Category: Littler, D | [[Category: Littler, D R.]] | ||
[[Category: MacKenzie, F.]] | [[Category: MacKenzie, F.]] | ||
[[Category: Newman, E | [[Category: Newman, E M.]] | ||
[[Category: SGC, Structural | [[Category: SGC, Structural Genomics Consortium.]] | ||
[[Category: Sundstrom, M.]] | [[Category: Sundstrom, M.]] | ||
[[Category: Walker, J | [[Category: Walker, J R.]] | ||
[[Category: Weigelt, J.]] | [[Category: Weigelt, J.]] | ||
[[Category: atp-binding]] | [[Category: atp-binding]] | ||
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[[Category: transferase]] | [[Category: transferase]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:22:14 2008'' | ||
