2fk0: Difference between revisions
New page: left|200px<br /><applet load="2fk0" size="350" color="white" frame="true" align="right" spinBox="true" caption="2fk0, resolution 2.95Å" /> '''Crystal Structure of... |
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==Overview== | ==Overview== | ||
The hemagglutinin (HA) structure at 2.9 angstrom resolution, from a highly | The hemagglutinin (HA) structure at 2.9 angstrom resolution, from a highly pathogenic Vietnamese H5N1 influenza virus, is more related to the 1918 and other human H1 HAs than to a 1997 duck H5 HA. Glycan microarray analysis of this Viet04 HA reveals an avian alpha2-3 sialic acid receptor binding preference. Introduction of mutations that can convert H1 serotype HAs to human alpha2-6 receptor specificity only enhanced or reduced affinity for avian-type receptors. However, mutations that can convert avian H2 and H3 HAs to human receptor specificity, when inserted onto the Viet04 H5 HA framework, permitted binding to a natural human alpha2-6 glycan, which suggests a path for this H5N1 virus to gain a foothold in the human population. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Stevens, J.]] | [[Category: Stevens, J.]] | ||
[[Category: Wilson, I | [[Category: Wilson, I A.]] | ||
[[Category: glycoprotein]] | [[Category: glycoprotein]] | ||
[[Category: membrane-fusion precursor]] | [[Category: membrane-fusion precursor]] | ||
[[Category: virus/viral protein]] | [[Category: virus/viral protein]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:22:08 2008'' | ||
Revision as of 18:22, 21 February 2008
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Crystal Structure of a H5N1 influenza virus hemagglutinin.
OverviewOverview
The hemagglutinin (HA) structure at 2.9 angstrom resolution, from a highly pathogenic Vietnamese H5N1 influenza virus, is more related to the 1918 and other human H1 HAs than to a 1997 duck H5 HA. Glycan microarray analysis of this Viet04 HA reveals an avian alpha2-3 sialic acid receptor binding preference. Introduction of mutations that can convert H1 serotype HAs to human alpha2-6 receptor specificity only enhanced or reduced affinity for avian-type receptors. However, mutations that can convert avian H2 and H3 HAs to human receptor specificity, when inserted onto the Viet04 H5 HA framework, permitted binding to a natural human alpha2-6 glycan, which suggests a path for this H5N1 virus to gain a foothold in the human population.
About this StructureAbout this Structure
2FK0 is a Protein complex structure of sequences from Influenza a virus (a/viet nam/1203/2004(h5n1)). Full crystallographic information is available from OCA.
ReferenceReference
Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virus., Stevens J, Blixt O, Tumpey TM, Taubenberger JK, Paulson JC, Wilson IA, Science. 2006 Apr 21;312(5772):404-10. Epub 2006 Mar 16. PMID:16543414
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