2fji: Difference between revisions

Revision as of 18:22, 21 February 2008

Crystal structure of the C-terminal domain of the exocyst subunit Sec6p

OverviewOverview

The exocyst is a conserved protein complex essential for trafficking secretory vesicles to the plasma membrane. The structure of the C-terminal domain of the exocyst subunit Sec6p reveals multiple helical bundles, which are structurally and topologically similar to Exo70p and the C-terminal domains of Exo84p and Sec15, despite <10% sequence identity. The helical bundles appear to be evolutionarily related molecular scaffolds that have diverged to create functionally distinct exocyst proteins.

About this StructureAbout this Structure

2FJI is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

ReferenceReference

The structure of the exocyst subunit Sec6p defines a conserved architecture with diverse roles., Sivaram MV, Furgason ML, Brewer DN, Munson M, Nat Struct Mol Biol. 2006 Jun;13(6):555-6. Epub 2006 May 14. PMID:16699513

Page seeded by OCA on Thu Feb 21 17:22:02 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:2fji.gif|left|200px]]<br /><applet load="2fji" size="450" color="white" frame="true" align="right" spinBox="true"
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 caption="2fji, resolution 2.40&Aring;" />
 '''Crystal structure of the C-terminal domain of the exocyst subunit Sec6p'''<br />
 ==Overview==
-The exocyst is a conserved protein complex essential for trafficking, secretory vesicles to the plasma membrane. The structure of the C-terminal, domain of the exocyst subunit Sec6p reveals multiple helical bundles, which are structurally and topologically similar to Exo70p and the, C-terminal domains of Exo84p and Sec15, despite &lt;10% sequence identity., The helical bundles appear to be evolutionarily related molecular, scaffolds that have diverged to create functionally distinct exocyst, proteins.
+The exocyst is a conserved protein complex essential for trafficking secretory vesicles to the plasma membrane. The structure of the C-terminal domain of the exocyst subunit Sec6p reveals multiple helical bundles, which are structurally and topologically similar to Exo70p and the C-terminal domains of Exo84p and Sec15, despite &lt;10% sequence identity. The helical bundles appear to be evolutionarily related molecular scaffolds that have diverged to create functionally distinct exocyst proteins.
 ==About this Structure==
-FJI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2FJI OCA].
+FJI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FJI OCA].
 ==Reference==
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 [[Category: Single protein]]
 [[Category: Munson, M.]]
-[[Category: Sivaram, M.V.]]
+[[Category: Sivaram, M V.]]
 [[Category: exocyst complex]]
 [[Category: exocytosis]]
 [[Category: tandem helical bundles]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 10:35:15 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:22:02 2008''