User:Michael Roberts/BIOL115 Chymo: Difference between revisions

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Click on the ''' 'green links' ''' in the text in the scrollable section below to examine this molecule in more detail.

== Tertiary structure ==

Chymotrypsin is initially synthesized as a 245 amino acid inactive precursor (a zymogen) termed chymotrypsinogen. Activation of chymotrypsinogen involves proteolytic cleavage at two sites along the chain and removal of two amino acids at each cleavage site. The resultant <scene name='User:Michael_Roberts/BIOL115_Chymo/Chains/1'>three chains</scene> are shown here (chain 1 = 1-13 in green; chain 2 = 16-146 in red; chain 3 = 149-24 in blue). Note, some amino acids at the temini of these chains are not shown in this representation (e.g. 11-13, 149, ). This is because these residues show too much flexibility in the crystal structures to give X-ray diffraction patterns which would locate them in space.

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 Click on the ''' 'green links' ''' in the text in the scrollable section below to examine this molecule in more detail.
-<StructureSection load='1afq' size='600' side='right' caption='Structure of bovine chymotrypsin (PDB entry [[1afq]])' scene='User:Michael_Roberts/BIOL115_Chymo/Start/1'>
+<StructureSection load='1afq' size='700' side='right' caption='Structure of bovine chymotrypsin (PDB entry [[1afq]])' scene='User:Michael_Roberts/BIOL115_Chymo/Start/1'>
 == Tertiary structure ==
 Chymotrypsin is initially synthesized as a 245 amino acid inactive precursor (a zymogen) termed chymotrypsinogen. Activation of chymotrypsinogen involves proteolytic cleavage at two sites along the chain and removal of two amino acids at each cleavage site. The resultant <scene name='User:Michael_Roberts/BIOL115_Chymo/Chains/1'>three chains</scene> are shown here (chain 1 = 1-13 in green; chain 2 = 16-146 in red; chain 3 = 149-24 in blue). Note, some amino acids at the temini of these chains are not shown in this representation (e.g. 11-13, 149, ). This is because these residues show too much flexibility in the crystal structures to give  X-ray diffraction patterns which would locate them in space.