Peroxisome Proliferator-Activated Receptors: Difference between revisions

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David Canner, Alexander Berchansky, Michal Harel, Joel L. Sussman

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-[[Image: 3dzy2.png|320px|left|thumb| Human PPARγ bound to RXRα and PPRE DNA strand, [[3dzy]]]]
+[[Image: 3dzy2.png|320px|left|thumb| Human PPARγ bound to RXRα and PPRE DNA strand, [[3dzy]]]]
The [[Peroxisome Proliferator-Activated Receptors]] (PPAR) α, γ, and δ are members of the nuclear receptor family. Since their discovery in the early 90s, it has become clear that the PPARs are essential modulators of external stimuli, acting as transcription factors to regulate mammalian metabolism, cellular differentiation, and tumorigenesis. The PPARs are the targets of numerous pharmaceutical drugs aimed at treating hypolipidemia and [[diabetes]] among other diseases.<ref name="Berger"/>  For details on PPARγ see [[PPAR-gamma]].
-{{STRUCTURE_3dzy| right| PDB=3dzy  | SCENE=Peroxisome_Proliferator-Activated_Receptors/Ppar_opening4/1 |CAPTION= Crystal Structure of Human PPARγ (green) complex with retinoic acid receptor RXR-α (blue), DNA, retinoic acid, LXXLL peptide (magenta and purple), [[3dzy]] }}
-The [[Peroxisome Proliferator-Activated Receptors]] (PPAR) α, γ, and δ are members of the nuclear receptor family. Since their discovery in the early 90s, it has become clear that the PPARs are essential modulators of external stimuli, acting as transcription factors to regulate mammalian metabolism, cellular differentiation, and tumorigenesis. The PPARs are the targets of numerous pharmaceutical drugs aimed at treating hypolipidemia and [[diabetes]] among other diseases.<ref name="Berger"/>  For details on PPARγ see [[PPAR-gamma]].
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 ==Biological Role==