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Suppression of RNA Silencing by Viruses: Difference between revisions

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Three structures, in particular, have provided insight into the basis for the molecular interactions involved in suppression of gene silencing (RNAi) by plant and animal viruses. Interestingly, the three proteins in these examples each employ a unique solution to bind the double stranded silencing RNA: [[Tomato aspermy virus protein 2b Suppression of RNA Silencing|one]] interacts with the major groove, [[Flock house virus B2 protein Suppression of RNA Silencing|one]] interacts mainly with the minor groove, and [[Plant Viral Protein p19 Suppression of RNA Silencing|one]] uses "molecular calipers" to measure the size of the silecing RNA.  In Proteopedia, there are separate detailed entries for each of these structures:
Three structures, in particular, have provided insight into the basis for the molecular interactions involved in suppression of gene silencing (RNAi) by plant and animal viruses. Interestingly, the three proteins in these examples each employ a unique solution to bind the double stranded silencing RNA: [[Tomato aspermy virus protein 2b Suppression of RNA Silencing|one]] interacts with the major groove, [[Flock house virus B2 protein Suppression of RNA Silencing|one]] interacts mainly with the minor groove, and [[Plant Viral Protein p19 Suppression of RNA Silencing|one]] uses "molecular calipers" to measure the size of the silecing RNA.  In Proteopedia, there are separate detailed entries for each of these structures:


::::::*[[Plant Viral Protein p19 Suppression of RNA Silencing]]
*[[Plant Viral Protein p19 Suppression of RNA Silencing]] <scene name='User:Wayne_Decatur/Plant_Viral_Protein_p19_Suppression_of_RNA_Silencing/View1/2'>Also click here</scene> ([[1rpu]])
::::::*[[Tomato aspermy virus protein 2b Suppression of RNA Silencing]]
*[[Tomato aspermy virus protein 2b Suppression of RNA Silencing]] <scene name='User:Wayne_Decatur/Tomato_aspermy_virus_protein_2b_Suppression_of_RNA_Silencing/View1withtrps/2'>Also click here</scene> ([[1r9f]])
::::::*[[Flock house virus B2 protein Suppression of RNA Silencing]]
*[[Flock house virus B2 protein Suppression of RNA Silencing]] <scene name='User:Wayne_Decatur/Tomato_aspermy_virus_protein_2b_Suppression_of_RNA_Silencing/View1withtrps/2'>Also click here</scene> ([[2zi0]])
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* <scene name='User:Wayne_Decatur/Plant_Viral_Protein_p19_Suppression_of_RNA_Silencing/View1/2'>Plant Viral Protein p19 Suppression of RNA Silencing|Carnation italian ringspot virus p19 bound to siRNA</scene> ([[1rpu]])
* <scene name='User:Wayne_Decatur/Tomato_aspermy_virus_protein_2b_Suppression_of_RNA_Silencing/View1withtrps/2'>Tomato aspermy virus protein 2b Suppression of RNA Silencing|Tomato aspermy virus protein 2b bound to siRNA</scene> ([[1r9f]])
* <scene name='User:Wayne_Decatur/Tomato_aspermy_virus_protein_2b_Suppression_of_RNA_Silencing/View1withtrps/2'>Flock house virus B2 protein Suppression of RNA Silencing|Flock house virus B2 protein bound to siRNA</scene> ([[2zi0]])
 
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==Related Structures and Topics==
==Related Structures and Topics==

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Wayne Decatur, David Canner, Alexander Berchansky, Michal Harel, Joel L. Sussman
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