Growth factor receptor-bound protein: Difference between revisions

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===GRB2===
===GRB2===


[[1ghu]] – hGRB2 SH2 domain (mutant) – human<br />
[[1gri]], [[2h46]] – hGRB2 – human <br />
[[1fhs]], [[1jyu]], [[2aoa]], [[2h46]] - hGRB2 SH2 domain<br />
[[2vvk]], [[2vwf]], [[2w0z]] - hGRB2 SH3 domain<br />
[[1tze]], [[1bmb]], [[1bm2]], [[1zfp]], [[1qg1]], [[1jyq]], [[1jyr]], [[2aob]], [[2h5k]], [[2huw]], [[3c7i]], [[3imd]], [[3imj]], [[3in7]], [[3in8]], [[3kfj]], [[3n8m]], [[3n7y]], [[3n84]], [[3mxc]], [[3mxy]], [[3ov1]], [[3ove]], [[3s8n]], [[3s8o]] - hGRB2 SH2 domain + phosphotyrosyl peptide<br />
[[1x0n]] - hGRB2 SH2 domain + inhibitor - NMR<br />
[[1cj1]] - hGRB2 SH2 domain + phosphotyrosyl derivative<br />
[[1gbq]], [[2gbq]], [[3gbq]], [[4gbq]], [[1aze]] - GRB2 SH3 domain + SOS-1 peptide – NMR<br />
[[1io6]], [[1h3h]] - GRB2 SH3 domain + ligand peptide – NMR


===GRB7===
''GRB2 C terminal SH3 domain''
 
[[1gfc]], [[1gfd]] – hGRB2 C terminal SH3 domain - NMR<br />
[[2vvk]], [[2vwf]], [[2w0z]] – hGRB2 C terminal SH3 domain <br />
[[1io6]] – hGRB2 C terminal SH3 domain + ligand peptide - NMR<br />
[[1gcq]] – hGRB2 C terminal SH3 domain + VAV proto-oncogene SH3 domain<br />
 
''GRB2 N terminal SH3 domain''
 
[[1gbr]], [[1gbq]], [[2gbq]], [[3gbq]], [[4gbq]] – mGRB2 N terminal SH3 domain + Sos-A peptide – mouse - NMR<br />
[[1aze]] – mGRB2 N terminal SH3 domain + Sos-A peptide - NMR<br />
 
''GRB2 SH2 domain''
 
[[1jyu]] – hGRB2 SH2 domain <br />
[[1ghu]] – hGRB2 SH2 domain (mutant) - NMR<br />
[[1fhs]] – hGRB2 SH2 domain - NMR<br />
[[1x0n]] – hGRB2 SH2 domain + inhibitor - NMR<br />
[[2huw]] – hGRB2 SH2 domain + cyclopropane derivative<br />
[[1cj1]] – hGRB2 SH2 domain + phosphor-Tyr derivative<br />
[[2aoa]], [[2aob]] – hGRB2 SH2 domain + peptide mimetic<br />
[[1tze]], [[1bmb]], [[1bm2]], [[1zfp]], [[1cj1]], [[1fyr]], [[1jyq]], [[1jyr]], [[2h5k]], [[3c7i]], [[3imd]], [[3imj]], [[3in7]], [[3in8]], [[3kfj]], [[3n8m]], [[3n7y]], [[3n84]], [[3mxc]], [[3mxy]], [[3ov1]], [[3ove]], [[3s8l]], [[3s8n]], [[3s8o]], [[1zfp]], [[1qg1]] – hGRB2 SH2 domain + phosphor-Tyr peptide<br />
[[1qg1]] – hGRB2 SH2 domain + phosphor-Tyr peptide - NMR<br />
 
===GRB4===
 
[[4e6r]] – hGRB4 C terminal SH3 domain <br />
 
===GRB7===  


[[1mw4]], [[2l4k]] – hGRB7 SH2 domain + receptor protein-tyrosine kinase ERBB-2 SH2 binding site – human – NMR<br />
[[2qms]] – hGRB7 SH2 domain <br />
[[2qms]] – hGRB7 SH2 domain <br />
[[3pqz]] – hGRB7 SH2 domain + cyclic peptide<br />
[[1mw4]] – hGRB7 SH2 domain + phosphor-Tyr peptide - NMR<br />
[[1wgr]] – hGRB7 RA domain – NMR<br />
[[2l4k]] – hGRB7 SH2 domain + phosphor-Tyr peptide - NMR<br />
[[3pqz]] – hGRB7 SH2 domain + cyclic peptide <br />
[[1wgr]] – hGRB7 RA domain - NMR<br />


===GRB10===
===GRB10===  


[[3hk0]] – hGRB10 RA+PH domains <br />
[[1nrv]] – hGRB10 SH2 domain <br />
[[1nrv]] – hGRB10 SH2 domain <br />
[[3m7f]] – hGRB10 SH2 domain + E3 ubiquitin-protein ligase NEDD4 C2 domain<br />
[[3m7f]] – hGRB10 SH2 domain + NEDD4 C2 domain<br />
[[3hk0]] – hGRB10 RA and PH domains <br />
 
===GRB14===
 
[[2aug]] – hGRB14 SH2 domain <br />
[[2auh]] – hGRB14 BPS domain + insulin receptor kinase domain<br />
 
 
 
 
 




Revision as of 15:08, 30 April 2013

<StructureSection load='1tze' size='400' side='right' caption='Structure of human Grb2 SH2 domain (pink) complex with phosphotyrosyl heptapeptide (gold) (PDB entry 1tze)' scene=>

Growth factor receptor-bound proteins (GRB) are adaptor proteins. GRB2 links the epidermal growth factor receptor tyrosine kinase to the activation of Ras and its downstream kinases. GRB2 contains an SH2 domain which binds tyrosine phosphorylated sequences and 2 SH3 domains which direct complex formation of proline-rich sequences. GRB2 is involved in signal transduction. GRB7 interacts with EGFR and ephrin receptors and plays a role in itegrin signalling pathway. GRB10 interacts with insulin receptor and insulin-like growth factor receptors. GRBs contain SH2, Ras-associated (RA) and pleckstrin homology (PH) domains. For additional details on GRB10 see Grb10 SH2 Domain.

3D structures of Grb3D structures of Grb

Updated on 30-April-2013

GRB2GRB2

1gri, 2h46 – hGRB2 – human

GRB2 C terminal SH3 domain

1gfc, 1gfd – hGRB2 C terminal SH3 domain - NMR
2vvk, 2vwf, 2w0z – hGRB2 C terminal SH3 domain
1io6 – hGRB2 C terminal SH3 domain + ligand peptide - NMR
1gcq – hGRB2 C terminal SH3 domain + VAV proto-oncogene SH3 domain

GRB2 N terminal SH3 domain

1gbr, 1gbq, 2gbq, 3gbq, 4gbq – mGRB2 N terminal SH3 domain + Sos-A peptide – mouse - NMR
1aze – mGRB2 N terminal SH3 domain + Sos-A peptide - NMR

GRB2 SH2 domain

1jyu – hGRB2 SH2 domain
1ghu – hGRB2 SH2 domain (mutant) - NMR
1fhs – hGRB2 SH2 domain - NMR
1x0n – hGRB2 SH2 domain + inhibitor - NMR
2huw – hGRB2 SH2 domain + cyclopropane derivative
1cj1 – hGRB2 SH2 domain + phosphor-Tyr derivative
2aoa, 2aob – hGRB2 SH2 domain + peptide mimetic
1tze, 1bmb, 1bm2, 1zfp, 1cj1, 1fyr, 1jyq, 1jyr, 2h5k, 3c7i, 3imd, 3imj, 3in7, 3in8, 3kfj, 3n8m, 3n7y, 3n84, 3mxc, 3mxy, 3ov1, 3ove, 3s8l, 3s8n, 3s8o, 1zfp, 1qg1 – hGRB2 SH2 domain + phosphor-Tyr peptide
1qg1 – hGRB2 SH2 domain + phosphor-Tyr peptide - NMR

GRB4GRB4

4e6r – hGRB4 C terminal SH3 domain

GRB7GRB7

2qms – hGRB7 SH2 domain
1mw4 – hGRB7 SH2 domain + phosphor-Tyr peptide - NMR
2l4k – hGRB7 SH2 domain + phosphor-Tyr peptide - NMR
3pqz – hGRB7 SH2 domain + cyclic peptide
1wgr – hGRB7 RA domain - NMR

GRB10GRB10

1nrv – hGRB10 SH2 domain
3m7f – hGRB10 SH2 domain + NEDD4 C2 domain
3hk0 – hGRB10 RA and PH domains

GRB14GRB14

2aug – hGRB14 SH2 domain
2auh – hGRB14 BPS domain + insulin receptor kinase domain

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Jaime Prilusky, Joel L. Sussman
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