Mitogen-activated protein kinase: Difference between revisions
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{{STRUCTURE_1erk| right| PDB=1erk | SCENE=Mitogen-activated_protein_kinase/Cv/1 |CAPTION=Mitogen-activated protein kinase, [[1erk]] }} | {{STRUCTURE_1erk| right| PDB=1erk | SCENE=Mitogen-activated_protein_kinase/Cv/1 |CAPTION=Mitogen-activated protein kinase, [[1erk]] }} | ||
[[Mitogen-activated protein kinase]] (MAPK) also known as Extracellular Signal-Regulated Kinase (ERK) are serine/threonine kinases which regulate various cellular activities in response to extracellular stimuli by mitogens, heat shock and more. MAPK is part of the MAPK cascade which consists of MAPK, [[Mitogen-activated protein kinase kinase|MAP2K]] and [[Mitogen-activated protein kinase kinase kinase|MAP3K]] which are activated by phosphorylation. MAPK1 and MAPK3 are activated in response to growth factors. MAPK6 is activated by phorbol esters. MAPK7 is activated by stress stimuli. MAPK8, MAPK9, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14 are stress-activated. MAPK11, MAPK12, MAPK13, MAPK14 belong to the class called p38 MAPK. images on the left and right correspond to one representative MAPK structure, ''i.e.'' the rat MAPK1 ([[1erk]]). | |||
[[Mitogen-activated protein kinase]] (MAPK) also known as Extracellular Signal-Regulated Kinase (ERK) are serine/threonine kinases which regulate various cellular activities in response to extracellular stimuli by mitogens, heat shock and more. MAPK is part of the MAPK cascade which consists of MAPK, [[Mitogen-activated protein kinase kinase|MAP2K]] and [[Mitogen-activated protein kinase kinase kinase|MAP3K]] which are activated by phosphorylation. MAPK1 and MAPK3 are activated in response to growth factors. MAPK6 is activated by phorbol esters. MAPK7 is activated by stress stimuli. MAPK8, MAPK9, MAPK10 (called also c-Jun N-terminal kinase 3 or JNK3), MAPK11, MAPK12, MAPK13, MAPK14 are stress-activated. MAPK11, MAPK12, MAPK13, MAPK14 belong to the class called p38 MAPK. images on the left and right correspond to one representative MAPK structure, ''i.e.'' the rat MAPK1 ([[1erk]]). | |||
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== 3D Structures of Mitogen-activated protein kinase == | == 3D Structures of Mitogen-activated protein kinase == | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | |||
===MAPK1=== | ===MAPK1=== | ||
[[3i5z]], [[3i60]], [[2e14]], [[2ojg]], [[2oji]], [[2ojj | [[3i5z]], [[3i60]], [[2e14]], [[2ojg]], [[2oji]], [[2ojj]], [[1wzy]], [[1tvo]] – hMAPK1+inhibitor - human<br /> | ||
[[2z7l]], [[3c9w]], [[3qyw]], [[3qyz]] - rMAPK1+inhibitor – rat<br /> | [[2z7l]], [[3c9w]], [[3qyw]], [[3qyz]] - rMAPK1+inhibitor – rat<br /> | ||
[[1erk]] - rMAPK1<br /> | [[1erk]] - rMAPK1<br /> | ||
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===MAPK10=== | ===MAPK10=== | ||
[[3kvx]], [[3fv8]], [[2waj]], [[3fi2]], [[3fi3]], [[3da6]], [[2zdt]], [[2zdu]], [[3cgf]], [[3cgo]], [[2r9s]], [[2o0u]], [[2o2u]], [[2exc]], [[2b1p]], [[1pmn]], [[1pmq]], [[1pmu]], [[1pmv]], [[3oy1]] – hMAPK10+inhibitor<br /> | [[3kvx]], [[3fv8]], [[2waj]], [[3fi2]], [[3fi3]], [[3da6]], [[2zdt]], [[2zdu]], [[3cgf]], [[3cgo]], [[2r9s]], [[2o0u]], [[2o2u]], [[2exc]], [[2b1p]], [[1pmn]], [[1pmq]], [[1pmu]], [[1pmv]], [[3oy1], [[2ok1]], [[3ttj]], [[3tti]], – hMAPK10+inhibitor<br /> | ||
[[3ptg]] - hMAPK10+JIP1 peptide <br /> | [[3ptg]], [[4h39]] - hMAPK10 catalytic domain + JIP1 peptide <br /> | ||
[[3g9l]], [[3g90]], [[3g9n]], [[2p33]] – hMAPK10 | [[4h36]] – hMAPK10 catalytic domain + ATF2 peptide<br /> | ||
[[4h3b]] – hMAPK10 catalytic domain + SAB peptide<br /> | |||
[[1jnk]] – hMAPK10 catalytic domain + AMPPNP<br /> | |||
[[3g9l]], [[3g90]], [[3g9n]], [[2p33]] – hMAPK10 catalytic domain+inhibitor<br /> | |||
[[3oxi]] - hMAPK10 + MAPK8 interacting protein + inhibitor<br /> | [[3oxi]] - hMAPK10 + MAPK8 interacting protein + inhibitor<br /> | ||