3oa1: Difference between revisions
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{{STRUCTURE_3oa1| PDB=3oa1 | SCENE= }} | {{STRUCTURE_3oa1| PDB=3oa1 | SCENE= }} | ||
===Crystal structure of phosphoprotein/Protein P/Protein M1 residues 69-297 from Rabies virus reveals degradation to C-terminal domain only=== | ===Crystal structure of phosphoprotein/Protein P/Protein M1 residues 69-297 from Rabies virus reveals degradation to C-terminal domain only=== | ||
==Function== | |||
[[http://www.uniprot.org/uniprot/PHOSP_RABVP PHOSP_RABVP]] Non catalytic polymerase cofactor and regulatory protein that plays a role in viral transcription and replication. Stabilizes the RNA polymerase L to the N-RNA template and binds the soluble protein N, preventing it from encapsidating non-genomic RNA. Also inhibits host IFN-alpha and IFN-beta signaling by binding and retaining phosphorylated STAT1 in the cytoplasm or by inhibiting the DNA binding of STAT1 in the nucleus. Might be involved, through interaction with host dynein, in intracellular microtubule-dependent virus transport of incoming virus from the synapse toward the cell body (By similarity). | |||
==About this Structure== | ==About this Structure== | ||
[[3oa1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rabies_virus_strain_pasteur_vaccin Rabies virus strain pasteur vaccin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OA1 OCA]. | |||
[[Category: Rabies virus strain pasteur vaccin]] | [[Category: Rabies virus strain pasteur vaccin]] | ||
[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]] | [[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]] | ||
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[[Category: Seattle structural genomics center for infectious disease]] | [[Category: Seattle structural genomics center for infectious disease]] | ||
[[Category: Ssgcid]] | [[Category: Ssgcid]] | ||