2f70: Difference between revisions
New page: left|200px<br /> <applet load="2f70" size="450" color="white" frame="true" align="right" spinBox="true" caption="2f70, resolution 2.120Å" /> '''Protein tyrosine p... |
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[[Image:2f70.gif|left|200px]]<br /> | [[Image:2f70.gif|left|200px]]<br /><applet load="2f70" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="2f70" size=" | |||
caption="2f70, resolution 2.120Å" /> | caption="2f70, resolution 2.120Å" /> | ||
'''Protein tyrosine phosphatase 1B with sulfamic acid inhibitors'''<br /> | '''Protein tyrosine phosphatase 1B with sulfamic acid inhibitors'''<br /> | ||
==Overview== | ==Overview== | ||
High-throughput screening of the P&GP corporate repository against several | High-throughput screening of the P&GP corporate repository against several protein tyrosine phosphatases identified the sulfamic acid moiety as potential phosphotyrosine mimetic. Incorporation of the sulfamic acid onto a 1,2,3,4-tetrahydroisoquinoline scaffold provided a promising starting point for PTP1B inhibitor design. | ||
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
2F70 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with MG, CL and UN6 as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] Full crystallographic information is available from [http:// | 2F70 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=CL:'>CL</scene> and <scene name='pdbligand=UN6:'>UN6</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F70 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Protein-tyrosine-phosphatase]] | [[Category: Protein-tyrosine-phosphatase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Evdokimov, A | [[Category: Evdokimov, A G.]] | ||
[[Category: Klopfenstein, S | [[Category: Klopfenstein, S R.]] | ||
[[Category: Pokross, M | [[Category: Pokross, M E.]] | ||
[[Category: CL]] | [[Category: CL]] | ||
[[Category: MG]] | [[Category: MG]] | ||
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[[Category: tyrosine]] | [[Category: tyrosine]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:18:21 2008'' | ||
