3ncc: Difference between revisions
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{{STRUCTURE_3ncc| PDB=3ncc | SCENE= }} | {{STRUCTURE_3ncc| PDB=3ncc | SCENE= }} | ||
===A human Prolactin receptor antagonist in complex with the mutant extracellular domain H188A of the human prolactin receptor=== | ===A human Prolactin receptor antagonist in complex with the mutant extracellular domain H188A of the human prolactin receptor=== | ||
{{ABSTRACT_PUBMED_20889499}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/PRL_HUMAN PRL_HUMAN]] Prolactin acts primarily on the mammary gland by promoting lactation. [[http://www.uniprot.org/uniprot/PRLR_HUMAN PRLR_HUMAN]] This is a receptor for the anterior pituitary hormone prolactin (PRL). Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.<ref>PMID:12580759</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[3ncc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NCC OCA]. | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:020889499</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Chayen, N E.]] | [[Category: Chayen, N E.]] | ||
| Line 36: | Line 23: | ||
[[Category: Hormone-hormone receptor complex]] | [[Category: Hormone-hormone receptor complex]] | ||
[[Category: Ph dependence]] | [[Category: Ph dependence]] | ||
Revision as of 14:49, 24 April 2013
A human Prolactin receptor antagonist in complex with the mutant extracellular domain H188A of the human prolactin receptorA human Prolactin receptor antagonist in complex with the mutant extracellular domain H188A of the human prolactin receptor
Template:ABSTRACT PUBMED 20889499
FunctionFunction
[PRL_HUMAN] Prolactin acts primarily on the mammary gland by promoting lactation. [PRLR_HUMAN] This is a receptor for the anterior pituitary hormone prolactin (PRL). Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.[1]
About this StructureAbout this Structure
3ncc is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Kulkarni MV, Tettamanzi MC, Murphy JW, Keeler C, Myszka DG, Chayen NE, Lolis EJ, Hodsdon ME. Two independent histidines, one in human prolactin and one in its receptor, are critical for pH dependent receptor recognition and activation. J Biol Chem. 2010 Sep 30. PMID:20889499 doi:10.1074/jbc.M110.172072