3o1u: Difference between revisions
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{{STRUCTURE_3o1u| PDB=3o1u | SCENE= }} | {{STRUCTURE_3o1u| PDB=3o1u | SCENE= }} | ||
===Iron-Catalyzed Oxidation Intermediates Captured in A DNA Repair Dioxygenase=== | ===Iron-Catalyzed Oxidation Intermediates Captured in A DNA Repair Dioxygenase=== | ||
{{ABSTRACT_PUBMED_021068844}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/ALKB_ECOLI ALKB_ECOLI]] Dioxygenase that repairs alkylated DNA and RNA containing 3-methylcytosine or 1-methyladenine by oxidative demethylation. Has highest activity towards 3-methylcytosine. Has lower activity towards alkylated DNA containing ethenoadenine, and no detectable activity towards 1-methylguanine or 3-methylthymine. Accepts double-stranded and single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron. Provides extensive resistance to alkylating agents such as MMS and DMS (SN2 agents), but not to MMNG and MNU (SN1 agents).<ref>PMID:12226668</ref> <ref>PMID:12594517</ref> <ref>PMID:16482161</ref> <ref>PMID:19706517</ref> <ref>PMID:21068844</ref> <ref>PMID:20084272</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[3o1u]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O1U OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:021068844</ref><references group="xtra"/><references/> | |||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Cui, Q.]] | [[Category: Cui, Q.]] | ||
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[[Category: Demethylase]] | [[Category: Demethylase]] | ||
[[Category: Oxidoreductase]] | [[Category: Oxidoreductase]] | ||