3o2t: Difference between revisions

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{{Seed}}
[[Image:3o2t.png|left|200px]]
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{{STRUCTURE_3o2t|  PDB=3o2t  |  SCENE=  }}  
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===Crystal structure of the N-terminal domain of human Symplekin===
===Crystal structure of the N-terminal domain of human Symplekin===
{{ABSTRACT_PUBMED_20861839}}


 
==Function==
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[[http://www.uniprot.org/uniprot/SYMPK_HUMAN SYMPK_HUMAN]] Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity.<ref>PMID:16230528</ref> <ref>PMID:20861839</ref> 
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{{ABSTRACT_PUBMED_20861839}}


==About this Structure==
==About this Structure==
3O2T is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O2T OCA].  
[[3o2t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O2T OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:20861839</ref><references group="xtra"/>
<ref group="xtra">PMID:020861839</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Tong, L.]]
[[Category: Tong, L.]]
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[[Category: Protein binding]]
[[Category: Protein binding]]
[[Category: Scaffold]]
[[Category: Scaffold]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 20 06:06:57 2010''

Revision as of 14:40, 24 April 2013

Template:STRUCTURE 3o2t

Crystal structure of the N-terminal domain of human SymplekinCrystal structure of the N-terminal domain of human Symplekin

Template:ABSTRACT PUBMED 20861839

FunctionFunction

[SYMPK_HUMAN] Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity.[1] [2]

About this StructureAbout this Structure

3o2t is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

[xtra 1]

  1. ↑ Xiang K, Nagaike T, Xiang S, Kilic T, Beh MM, Manley JL, Tong L. Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex. Nature. 2010 Sep 22. PMID:20861839 doi:10.1038/nature09391
  1. ↑ Kolev NG, Steitz JA. Symplekin and multiple other polyadenylation factors participate in 3'-end maturation of histone mRNAs. Genes Dev. 2005 Nov 1;19(21):2583-92. Epub 2005 Oct 17. PMID:16230528 doi:10.1101/gad.1371105
  2. ↑ Xiang K, Nagaike T, Xiang S, Kilic T, Beh MM, Manley JL, Tong L. Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex. Nature. 2010 Sep 22. PMID:20861839 doi:10.1038/nature09391

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